Biocompatible Polyurethane Scaffolds Prepared from Glycerol Monostearate-Derived Polyester Polyol

Journal Article · Sun Jul 15 04:00:00 EDT 2018 · Journal of Polymers and the Environment

DOI:https://doi.org/10.1007/S10924-017-1175-2· OSTI ID:22791377

Ng, Wei Seng ^[1]; Lee, Choy Sin ^[2]; Cheng, Sit-Foon; Chuah, Cheng Hock ^[1]; Wong, Shew Fung ^[2]

---

1. University of Malaya, Unit of Research on Lipids (URL), Department of Chemistry, Faculty of Science (Malaysia)
2. International Medical University, Department of Pharmaceutical Chemistry, School of Pharmacy (Malaysia)

Biodegradable polyester polyol was synthesized from oleochemical glycerol monostearate (GMS) and glutaric acid under a non-catalyzed and solvent-free polycondensation method. The chemical structure of GMS-derived polyester polyol (GPP) was elucidated by FTIR, {sup 1}H and {sup 13}C NMR, and molecular weight of GPP was characterized by GPC. The synthesized GPP with acid value of 3.03 mg KOH/g sample, hydroxyl value of 115.72 mg KOH/g sample and M{sub n} of 1345 g/mol was incorporated with polyethylene glycol (PEG) and polycaprolactone diol (PCL diol) to produce a water-blown porous polyurethane system via one-shot foaming method. The polyurethanes were optimized by evaluating glycerol as a crosslinker, silicone surfactant and water blowing agent on tensile properties of polyurethanes. All polyurethanes underwent structural change, and crystalline hard segments of polyurethanes were shifted to higher temperature suggested that hard segments undergone re-ordering process during enzymatic treatment. In terms of biocompatibility, polyurethane scaffold produced by reacting 100% w/w of GPP with isophorone diisocyanate and additives showed the highest cells viability of 3T3 mouse fibroblast (94%, day 1), and MG63 human osteosarcoma (107%, day 1) and better cell adhesion as compared to reference polyurethane produced by only PEG and PCL diol (3T3 cell viability: 8%; MG63 cell viability: 2%). The current work demonstrated GPP synthesized from renewable and environmental friendly resources produced polyurethanes that allows improvement in physico-chemical, mechanical and biocompatibility properties. By blending with increasing content of GPP, the water-blown porous polyurethane scaffold has shown great potential as biomaterial for soft and hard tissue engineering.

• OSTI ID: 22791377
• Journal Information: Journal of Polymers and the Environment, Journal Name: Journal of Polymers and the Environment Journal Issue: 7 Vol. 26; ISSN 1566-2543
• Country of Publication: United States
• Language: English

Related Subjects

36 MATERIALS SCIENCE
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
ANIMAL TISSUES
BIOLOGICAL MATERIALS
CARBON 13
FIBROBLASTS
FOURIER TRANSFORM SPECTROMETERS
GLUTARIC ACID
GLYCEROL
HYDROGEN 1
MOLECULAR WEIGHT
NUCLEAR MAGNETIC RESONANCE
OSTEOSARCOMAS
POLYESTERS
POLYETHYLENE GLYCOLS
POLYURETHANES
POROUS MATERIALS
POTASSIUM HYDROXIDES
SILICONES
SURFACTANTS
TENSILE PROPERTIES