Preparation and Characterization of Magnetite–Chitosan Nanoparticles and Evaluation of Their Cytotoxicity Effects on MCF7 and Fibroblast Cells

Journal Article · Fri Dec 15 00:00:00 EST 2017 · Journal of Superconductivity and Novel Magnetism

DOI:https://doi.org/10.1007/S10948-017-4094-5· OSTI ID:22771755

Lotfi, Sheida; Ghaderi, Fahimeh; Bahari, Ali ^[1]; Mahjoub, Soleiman ^[2]

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1. University of Mazandaran, Department of Solid State Physics (Iran, Islamic Republic of)
2. Babol University of Medical Sciences, Cellular and Molecular Biology Research Center, Health Research Institute (Iran, Islamic Republic of)

Nowadays, magnetic nanoparticles play a key role in drug treatment. However, if they are uncoated, they might aggregate and cause embolism in drug delivery. To avoid this, they are generally coated with polymers. In this investigation, magnetic nanoparticles (MNPs) were coated with chitosan through in situ co-precipitation process and their properties in addition to their cytotoxicity in MCF7 and fibroblast cells were analyzed. The results showed MNPs–chitosan nanoparticles would contain an average mean diameter of 32 nm and a saturation magnetization (M{sub S}) value of 38.87 emu/g. To characterize the synthesized nanoparticles in terms of structural, morphological and magnetic properties, Fourier transform infrared (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermal gravimetric analysis (TGA) and vibrating sample magnetometry (VSM) studies were used. Toxicity test was also done to investigate whether their presence would cause any toxicity in the body; in addition, antibacterial assay was done to analyze if nanoparticles could be used as an antimicrobial agent.

• OSTI ID: 22771755
• Journal Information: Journal of Superconductivity and Novel Magnetism, Vol. 30, Issue 12; Other Information: Copyright (c) 2017 Springer Science+Business Media, LLC, part of Springer Nature; Article Copyright (c) 2017 Springer Science+Business Media New York; http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA); ISSN 1557-1939
• Country of Publication: United States
• Language: English

Related Subjects

75 CONDENSED MATTER PHYSICS
SUPERCONDUCTIVITY AND SUPERFLUIDITY
ANTIMICROBIAL AGENTS
COPRECIPITATION
DRUG DELIVERY
FIBROBLASTS
INFRARED SPECTRA
MAGNETIC PROPERTIES
MAGNETITE
MAGNETIZATION
NANOPARTICLES
OLIGOSACCHARIDES
POLYMERS
SCANNING ELECTRON MICROSCOPY
THERMAL GRAVIMETRIC ANALYSIS
TOXICITY
TRANSMISSION ELECTRON MICROSCOPY
VIBRATING SAMPLE MAGNETOMETERS
X-RAY DIFFRACTION