Magnetite Nanoparticles Coated with Rifampicin and Chlortetracycline for Drug Delivery Applications
- Faculty of Physics, Alexandru Ioan Cuza University of Iasi, 11A Carol I Bd., 700506, Iasi (Romania)
- National Institute of Research and Development for Technical Physics, 7 Mangeron Bd., Iasi (Romania)
Four types of biocompatible magnetic fluids based on superparamagnetic nanoparticles with Fe{sub 3}O{sub 4} cores were functionalized with antibiotics (rifampicin or chlortetracycline) as potential candidates for in vivo biomedical applications, such as magnetically controlled drug delivery. The synthesis consisted in coprecipitation of iron oxide in basic, as well as in acid medium, followed by the dispersion of the resulted magnetite nanoparticles in aqueous solution containing the antibiotic. The chosen method to prepare the magnetite-core/drug-shell systems avoided intermediate organic coating of the magnetic nanoparticles. Comparative analysis of the rheological features of the aqueous magnetic fluid samples was performed. The structural features of the coated magnetic particles were investigated by X-Ray Diffraction (XRD), Transmission Electron Microscopy (TEM) and Vibrating Sample Magnetometry (VSM). Good crystallinity and adequate stability in time were evidenced. Drug delivery curves were spectrophotometrically provided.
- OSTI ID:
- 21506935
- Journal Information:
- AIP Conference Proceedings, Vol. 1311, Issue 1; Conference: 8. international conference on the scientific and clinical applications of magnetic carriers, Rostock (Germany), 25-29 May 2010; Other Information: DOI: 10.1063/1.3530043; (c) 2010 American Institute of Physics; ISSN 0094-243X
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
AQUEOUS SOLUTIONS
COPRECIPITATION
DELIVERY
FERRITES
FLUIDS
IN VIVO
IRON OXIDES
MAGNETITE
NANOSTRUCTURES
SCANNING ELECTRON MICROSCOPY
STABILITY
SUPERPARAMAGNETISM
SYNTHESIS
TETRACYCLINES
TRANSMISSION ELECTRON MICROSCOPY
VIBRATING SAMPLE MAGNETOMETERS
X-RAY DIFFRACTION
ANTIBIOTICS
ANTI-INFECTIVE AGENTS
CHALCOGENIDES
COHERENT SCATTERING
DIFFRACTION
DISPERSIONS
DRUGS
ELECTRON MICROSCOPY
FERRIMAGNETIC MATERIALS
HOMOGENEOUS MIXTURES
IRON COMPOUNDS
IRON ORES
MAGNETIC MATERIALS
MAGNETISM
MAGNETOMETERS
MATERIALS
MEASURING INSTRUMENTS
MICROSCOPY
MINERALS
MIXTURES
ORES
ORGANIC COMPOUNDS
OXIDE MINERALS
OXIDES
OXYGEN COMPOUNDS
PRECIPITATION
SCATTERING
SEPARATION PROCESSES
SOLUTIONS
TRANSITION ELEMENT COMPOUNDS