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Title: Fibrolamellar Hepatocellular Carcinoma: Treatment with Yttrium-90 and Subsequent Surgical Resection

Abstract

We describe a 52-year-old female patient who presented with a 9.5-cm fibrolamellar hepatocellular carcinoma (FL-HCC). The patient was initially unsuitable for surgical resection and therefore underwent transarterial chemoembolization followed by selective internal radiation therapy (SIRT) with Yttrium-90 to downsize the tumour. Following SIRT, the tumour decreased in volume from 350 to 20 cm{sup 3} allowing curative (R0) resection with an extended left hepatectomy and reconstruction of IVC. This is the first reported case of FL-HCC treated with SIRT in which, due to the good SIRT response, the patient was downsized to allow curative resection.

Authors:
 [1];  [2];  [3];  [4];  [2];  [1]
  1. Freeman Hospital, Department of Interventional Radiology (United Kingdom)
  2. Freeman Hospital, Department of Hepatobiliary Surgery (United Kingdom)
  3. Newcastle University, Institute of Cellular Medicine, Faculty of Medical Sciences (United Kingdom)
  4. Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust, Department of Cellular Pathology (United Kingdom)
Publication Date:
OSTI Identifier:
22750027
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 41; Journal Issue: 5; Other Information: Copyright (c) 2018 Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Article Copyright (c) 2018 The Author(s); http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; HEPATOMAS; PATIENTS; YTTRIUM 90

Citation Formats

Mafeld, Sebastian, French, Jeremy, Tiniakos, Dina, Haugk, Beate, Manas, Derek, and Littler, Peter. Fibrolamellar Hepatocellular Carcinoma: Treatment with Yttrium-90 and Subsequent Surgical Resection. United States: N. p., 2018. Web. doi:10.1007/S00270-018-1903-6.
Mafeld, Sebastian, French, Jeremy, Tiniakos, Dina, Haugk, Beate, Manas, Derek, & Littler, Peter. Fibrolamellar Hepatocellular Carcinoma: Treatment with Yttrium-90 and Subsequent Surgical Resection. United States. doi:10.1007/S00270-018-1903-6.
Mafeld, Sebastian, French, Jeremy, Tiniakos, Dina, Haugk, Beate, Manas, Derek, and Littler, Peter. Tue . "Fibrolamellar Hepatocellular Carcinoma: Treatment with Yttrium-90 and Subsequent Surgical Resection". United States. doi:10.1007/S00270-018-1903-6.
@article{osti_22750027,
title = {Fibrolamellar Hepatocellular Carcinoma: Treatment with Yttrium-90 and Subsequent Surgical Resection},
author = {Mafeld, Sebastian and French, Jeremy and Tiniakos, Dina and Haugk, Beate and Manas, Derek and Littler, Peter},
abstractNote = {We describe a 52-year-old female patient who presented with a 9.5-cm fibrolamellar hepatocellular carcinoma (FL-HCC). The patient was initially unsuitable for surgical resection and therefore underwent transarterial chemoembolization followed by selective internal radiation therapy (SIRT) with Yttrium-90 to downsize the tumour. Following SIRT, the tumour decreased in volume from 350 to 20 cm{sup 3} allowing curative (R0) resection with an extended left hepatectomy and reconstruction of IVC. This is the first reported case of FL-HCC treated with SIRT in which, due to the good SIRT response, the patient was downsized to allow curative resection.},
doi = {10.1007/S00270-018-1903-6},
journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 5,
volume = 41,
place = {United States},
year = {2018},
month = {5}
}