A revisited concept: Contact inhibition of growth. From cell biology to malignancy

Journal Article · Sun Oct 01 04:00:00 EDT 2017 · Experimental Cell Research

DOI:https://doi.org/10.1016/J.YEXCR.2017.06.012· OSTI ID:22738162

Ribatti, Domenico

In cell biology, contact inhibition refers to two different but closely related phenomena, contact inhibition of locomotion and contact inhibition of proliferation, exhibited by fibroblasts when in contact with one another. Normal fibroblasts migrate across the surface of a culture dish until they make contact with a neighboring cell. Further cell migration is then inhibited, and normal cells adhere to each other, forming an orderly array of cells on the culture dish surface. Tumor cells, in contrast, continue moving after contact with their neighbors, migrating over adjacent cells, and growing in disordered, multilayered patterns. Not only the movement but also the proliferation of many normal cells is inhibited by cell-cell contact, and cancer cells are characteristically insensitive to such contact inhibition. - Highlights: • Contact inhibition refers to contact inhibition of locomotion and of proliferation. • Normal fibroblasts migrate across a culture dish until they make contact with a neighboring cell. • Tumor cells, in contrast, continue moving after contact with their neighbors.

• OSTI ID: 22738162
• Journal Information: Experimental Cell Research, Journal Name: Experimental Cell Research Journal Issue: 1 Vol. 359; ISSN 0014-4827; ISSN ECREAL
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
BIOLOGY
CELL CULTURES
FIBROBLASTS
INHIBITION
NEOPLASMS
TUMOR CELLS