Effects of a co-micronized composite containing palmitoylethanolamide and polydatin in an experimental model of benign prostatic hyperplasia

Journal Article · Tue Aug 15 04:00:00 EDT 2017 · Toxicology and Applied Pharmacology

DOI:https://doi.org/10.1016/J.TAAP.2017.06.005· OSTI ID:22722901

Cordaro, Marika; Impellizzeri, Daniela; Siracusa, Rosalba; Gugliandolo, Enrico; Fusco, Roberta ^[1]; Inferrera, Antonino ^[2]; Esposito, Emanuela; Di Paola, Rosanna ^[1]; Cuzzocrea, Salvatore ^[1]

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1. Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina (Italy)
2. Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, AUO “Gaetano Martino”, Via Consolare Valeria 1, 98125 Messina (Italy)

Palmitoylethanolamide (PEA), a fatty acid amide-signaling molecule has well-known anti-inflammatory and neuroprotective effects. Nevertheless, PEA does not possess the ability to prevent free radicals formation. Polydatin (PLD), a biological precursor of resveratrol, has antioxidant activity. A combination of PEA and PLD could, conceivably, have beneficial effects on oxidative stress produced by inflammatory processes. In the present study we investigated the effects of a co-micronized composite containing PEA and PLD (m(PEA/PLD)) in a model of testosterone-induced benign hyperplasia (BPH). BPH was provoked in rats by daily administration of testosterone propionate (3 mg/kg) for 14 days. This protocol leads to alterations in prostate morphology and increased levels of prostaglandin E2 and dihydrotestosterone as well as of 5α-reductase 1 and 5α-reductase 2 expression. Moreover, testosterone induced marked inflammation in terms of an increase in nuclear translocation of nuclear factor-κB p65 and consequently in IκB-α degradation as well as disregulation of inducible nitric oxide synthase, cyclooxygenase-2 and manganese superoxide dismutase expression and in the apoptosis pathway. Our results show, for the first time, that m(PEA/PLD) is capable of decreasing prostate weight and dihydrotestosterone production in BPH-induced rats. These effects were most likely correlated to the anti-inflammatory and apoptotic effects of m(PEA/PLD). Accordingly, these results support the view that m(PEA/PLD) should be further studied as a potent candidate for the management of BPH. - Highlights: • Chronic inflammation has emerged as a potential factor in the pathogenesis of BPH. • We evaluate the effects of m(PEA/PLD) in terms of impact on the inflammatory process and oxidative stress in BPH. • m(PEA/PLD) should be further explored as a valid candidate for the treatment of BPH.

• OSTI ID: 22722901
• Journal Information: Toxicology and Applied Pharmacology, Journal Name: Toxicology and Applied Pharmacology Vol. 329; ISSN TXAPA9; ISSN 0041-008X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
AMIDES
CARBOXYLIC ACIDS
ENERGY BEAM DEPOSITION
INFLAMMATION
LASER RADIATION
NITRIC OXIDE
OXIDATION
PEAS
PULSED IRRADIATION
SUPEROXIDE DISMUTASE
TESTOSTERONE