Androgen-responsive circular RNA circSMARCA5 is up-regulated and promotes cell proliferation in prostate cancer

Journal Article · Sat Nov 25 00:00:00 EST 2017 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/J.BBRC.2017.07.162· OSTI ID:22719145

Kong, Zhe; Wan, Xuechao; Zhang, Yalong; Zhang, Pu ^[1]; Zhang, Yingyi ^[2]; Zhang, Xiaona; Qi, Xiaoxiang ^[3]; Wu, Hai ^[1]; Huang, Jianfeng ^[3]; Li, Yao ^[1]

---

1. State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, 200433 (China)
2. Department of Oncology, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai 200433 (China)
3. Shanghai Biotechnology Corporation, Shanghai 201203 (China)

Prostate cancer (PCa) is one of the most commonly diagnosed cancers in males worldwide. Circular RNA (circRNA) is a unique class of RNA transcribed by RNA polymerase II characterized by jointing 3′ and 5′ ends together via exon or intron circularization. However, the molecular functions of circRNAs in prostate cancer have rarely been explored. In present study, we found circ-SMARCA5 was up-regulated in prostate cancer samples compared to match normal tissues. We also observed circ-SMARCA5 expression was significantly induced after DHT treatment. Functional experiments showed circ-SMARCA5 acted as an oncogene in prostate cancer by promoting cell cycle and inhibiting cell apoptosis. We thought this study provided useful information for exploring circRNAs as potential therapeutic and prognostic targets for prostate cancer. - Highlights: • To our knowledge, this is the first study to explore the molecular functions of circRNA in prostate cancer. • Our study showed that circ-SMARCA5 promoted cell proliferation and inhibited cell apoptosis in prostate cancer. • circ-SMARCA5 was for the first time reported as an androgen-responsive circRNA. • circ-SMARCA5 was for the first time reported to be up-regulated in prostate cancer.

• OSTI ID: 22719145
• Journal Information: Biochemical and Biophysical Research Communications, Vol. 493, Issue 3; Other Information: Copyright (c) 2017 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ANDROGENS
ANIMAL TISSUES
APOPTOSIS
CELL CYCLE
CELL PROLIFERATION
DIAGNOSIS
EXONS
NEOPLASMS
ONCOGENES
PROSTATE
RNA
RNA POLYMERASES