TU-H-CAMPUS-TeP3-02: In-Situ Dose Painting Using Gold Nanoparticles Released From Cylindrically Shaped Fiducials During External Beam Radiation Therapy
- Brigham and Women’s Hospital, Boston, MA (United States)
- University of Massachusetts Lowell, Lowell, MA (United States)
- University Medical Center Mannheim, Mannheim (Germany)
- Harvard Medical School, Boston, MA (United States)
Purpose: Recent studies have shown that the presence of Gold Nanoparticles (GNPs) in tumor tissue can lead to significant dose enhancement (DE) during External Beam Radiation Therapy (EBRT). In this in-silico study we investigate EBRT with in-situ dose painting using GNPs released from cylindrically shaped GNP-loaded fiducials. Methods: Reported Biologically Target/Tumor Volumes (BTVs) for 12 prostate carcinoma patients were employed in this study. Distribution of the GNPs after burst release from the fiducial (1.5mm diameter and 5mm length) located in the center of the spherically assumed BTV were modeled by isotropic and free diffusion without boundary condition and under the assumption of superposition. An experimentally determined diffusion coefficient for 10nm nanoparticles was adapted for investigating other GNP sizes (2, 5, 15, and 20nm) using the Stokes-Einstein equation. The maximum size of GNPs to achieve a minimal DE Factor (DEF) of 1.1 for 6MV EBRT using a fiducial-load of 30mg/g was calculated for typical periods of 14 and 21 days after implantation. Further, the minimal fiducial-load needed to achieve a clinically significant DEF of 1.2 was computed for 2nm GNPs. Results: Results showed that a minimal DEF of 1.1 could be reached for the smallest patient BTV using a maximal GNP size of 10nm and 20nm after 14 and 21 days, respectively. With increasing BTV smaller GNPs are required to ensure the same DEF. In particular, the largest BTV requires 2nm GNPs for periods of 14 and 21 days. Meanwhile, the required fiducial-load to reach a minimal DEF of 1.2 after 14 days was found in the range of 17mg/g and 59mg/g for all reported BTVs. Conclusion: This preliminary study indicates a strong dependence on GNP size and fiducial-load to realize a significant DE. The findings avail further research towards development of GNP-loaded fiducials for significantly enhancing radiotherapy for cancer patients.
- OSTI ID:
- 22654078
- Journal Information:
- Medical Physics, Vol. 43, Issue 6; Other Information: (c) 2016 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-2405
- Country of Publication:
- United States
- Language:
- English
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