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Title: Patterns of Relapse in High-Risk Neuroblastoma Patients Treated With and Without Total Body Irradiation

Abstract

Purpose: External beam radiation therapy to initial sites of disease may influence relapse patterns in high-risk neuroblastoma. However, the effect of systemic irradiation by use of total body irradiation (TBI) on anatomic patterns of relapse has not previously been investigated. Methods and Materials: We retrospectively analyzed patients receiving definitive treatment of high-risk neuroblastoma with subsequent relapse in bony metastatic sites, with a date of relapse between January 1, 1997, and December 31, 2012. Anatomic sites of disease, defined by metaiodobenzylguanidine (MIBG) avidity, were compared at diagnosis and at first relapse. The Fisher exact test was performed to compare relapse in initially involved sites between patients treated with and without TBI. Results: Seventy-four patients with a median age at diagnosis of 3.5 years (range, 0.3-15.3 years) had relapse in 227 sites of MIBG-avid metastatic disease, with a median time to relapse of 1.8 years. Of the 227 sites of first relapse, 154 sites (68%) were involved at diagnosis. When we compared relapse patterns in patients treated with and without TBI, 12 of 23 patients (52%) treated with TBI had relapse in ≥1 previously MIBG-avid site of disease whereas 40 of 51 patients (78%) treated without TBI had relapse in ≥1 previously MIBG-avid site ofmore » disease (P=.03). Conclusions: Patients treated with systemic irradiation in the form of TBI were significantly less likely to have relapse in prior sites of disease. These findings support further investigation into the role of radiopharmaceutical therapies in curative multimodality therapy.« less

Authors:
 [1];  [2];  [3];  [1];  [2];  [3];  [4];  [5];  [1];  [2];  [6];  [4];  [2];  [1];  [2];  [1];  [2];  [2];  [3];  [1] more »;  [2]; « less
  1. Harvard Medical School, Boston, Massachusetts (United States)
  2. (United States)
  3. School of Medicine, University of California San Francisco, San Francisco, California (United States)
  4. Brigham and Women's Hospital, Boston, Massachusetts (United States)
  5. Children's Hospital of Philadelphia, Philadelphia, Pennsylvania (United States)
  6. Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (United States)
Publication Date:
OSTI Identifier:
22645763
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 97; Journal Issue: 2; Other Information: Copyright (c) 2016 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; DIAGNOSIS; EXTERNAL BEAM RADIATION THERAPY; NEOPLASMS; PATIENTS; RADIATION HAZARDS; WHOLE-BODY IRRADIATION

Citation Formats

Li, Richard, Brigham and Women's Hospital, Boston, Massachusetts, Polishchuk, Alexei, DuBois, Steven, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, Hawkins, Randall, Lee, Stephanie W., Bagatell, Rochelle, Shusterman, Suzanne, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, Hill-Kayser, Christine, Al-Sayegh, Hasan, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, Diller, Lisa, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, Haas-Kogan, Daphne A., Brigham and Women's Hospital, Boston, Massachusetts, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, Matthay, Katherine K., London, Wendy B., Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, and and others. Patterns of Relapse in High-Risk Neuroblastoma Patients Treated With and Without Total Body Irradiation. United States: N. p., 2017. Web. doi:10.1016/J.IJROBP.2016.10.047.
Li, Richard, Brigham and Women's Hospital, Boston, Massachusetts, Polishchuk, Alexei, DuBois, Steven, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, Hawkins, Randall, Lee, Stephanie W., Bagatell, Rochelle, Shusterman, Suzanne, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, Hill-Kayser, Christine, Al-Sayegh, Hasan, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, Diller, Lisa, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, Haas-Kogan, Daphne A., Brigham and Women's Hospital, Boston, Massachusetts, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, Matthay, Katherine K., London, Wendy B., Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, & and others. Patterns of Relapse in High-Risk Neuroblastoma Patients Treated With and Without Total Body Irradiation. United States. doi:10.1016/J.IJROBP.2016.10.047.
Li, Richard, Brigham and Women's Hospital, Boston, Massachusetts, Polishchuk, Alexei, DuBois, Steven, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, Hawkins, Randall, Lee, Stephanie W., Bagatell, Rochelle, Shusterman, Suzanne, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, Hill-Kayser, Christine, Al-Sayegh, Hasan, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, Diller, Lisa, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, Haas-Kogan, Daphne A., Brigham and Women's Hospital, Boston, Massachusetts, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, Matthay, Katherine K., London, Wendy B., Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, and and others. Wed . "Patterns of Relapse in High-Risk Neuroblastoma Patients Treated With and Without Total Body Irradiation". United States. doi:10.1016/J.IJROBP.2016.10.047.
@article{osti_22645763,
title = {Patterns of Relapse in High-Risk Neuroblastoma Patients Treated With and Without Total Body Irradiation},
author = {Li, Richard and Brigham and Women's Hospital, Boston, Massachusetts and Polishchuk, Alexei and DuBois, Steven and Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts and Hawkins, Randall and Lee, Stephanie W. and Bagatell, Rochelle and Shusterman, Suzanne and Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts and Hill-Kayser, Christine and Al-Sayegh, Hasan and Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts and Diller, Lisa and Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts and Haas-Kogan, Daphne A. and Brigham and Women's Hospital, Boston, Massachusetts and Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts and Matthay, Katherine K. and London, Wendy B. and Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts and and others},
abstractNote = {Purpose: External beam radiation therapy to initial sites of disease may influence relapse patterns in high-risk neuroblastoma. However, the effect of systemic irradiation by use of total body irradiation (TBI) on anatomic patterns of relapse has not previously been investigated. Methods and Materials: We retrospectively analyzed patients receiving definitive treatment of high-risk neuroblastoma with subsequent relapse in bony metastatic sites, with a date of relapse between January 1, 1997, and December 31, 2012. Anatomic sites of disease, defined by metaiodobenzylguanidine (MIBG) avidity, were compared at diagnosis and at first relapse. The Fisher exact test was performed to compare relapse in initially involved sites between patients treated with and without TBI. Results: Seventy-four patients with a median age at diagnosis of 3.5 years (range, 0.3-15.3 years) had relapse in 227 sites of MIBG-avid metastatic disease, with a median time to relapse of 1.8 years. Of the 227 sites of first relapse, 154 sites (68%) were involved at diagnosis. When we compared relapse patterns in patients treated with and without TBI, 12 of 23 patients (52%) treated with TBI had relapse in ≥1 previously MIBG-avid site of disease whereas 40 of 51 patients (78%) treated without TBI had relapse in ≥1 previously MIBG-avid site of disease (P=.03). Conclusions: Patients treated with systemic irradiation in the form of TBI were significantly less likely to have relapse in prior sites of disease. These findings support further investigation into the role of radiopharmaceutical therapies in curative multimodality therapy.},
doi = {10.1016/J.IJROBP.2016.10.047},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 2,
volume = 97,
place = {United States},
year = {Wed Feb 01 00:00:00 EST 2017},
month = {Wed Feb 01 00:00:00 EST 2017}
}