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Title: Indwelling Stent Embedded with Light-Emitting Diodes for Photodynamic Therapy of Malignant Biliary Obstruction

Abstract

PurposeWe describe the design and preliminary characterization of a stent incorporating light-emitting diodes (LEDs) for photodynamic therapy (PDT) of malignant biliary obstruction.MethodsA prototype was constructed with red (640 nm) LEDs embedded in a 14.5 French polyurethane tube. The device was evaluated for optical power and subjected to physical and electrical tests. PDT-induced reactive oxygen species were imaged in a gel phantom.ResultsThe stent functioned at a 2.5-cm bend radius and illuminated for 6 months in saline. No stray currents were detected, and it was cool after 30 minutes of operation. Optical power of 5–15 mW is applicable to PDT. Imaging of a reactive oxygen indicator showed LED-stent activation of photosensitizer.ConclusionsThe results motivate biological testing and design optimization.

Authors:
 [1];  [2]; ;  [1]
  1. University of Rochester Medical Center, Department of Imaging Sciences (United States)
  2. University Health Network, The Joint Department of Medical Imaging (Canada)
Publication Date:
OSTI Identifier:
22642519
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 39; Journal Issue: 6; Other Information: Copyright (c) 2016 Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); http://www.springer-ny.com; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BIOASSAY; BIOMEDICAL RADIOGRAPHY; FRANCE; GELS; IMAGES; LIGHT EMITTING DIODES; OPTIMIZATION; OXYGEN; PHANTOMS; POLYURETHANES; THERAPY; VISIBLE RADIATION

Citation Formats

Baran, Timothy M., E-mail: timothy.baran@rochester.edu, Mironov, Oleg, E-mail: oleg.mironov@uhn.ca, Sharma, Ashwani K., E-mail: Ashwani-Sharma@URMC.Rochester.edu, and Foster, Thomas H., E-mail: thomas.foster@rochester.edu. Indwelling Stent Embedded with Light-Emitting Diodes for Photodynamic Therapy of Malignant Biliary Obstruction. United States: N. p., 2016. Web. doi:10.1007/S00270-015-1241-X.
Baran, Timothy M., E-mail: timothy.baran@rochester.edu, Mironov, Oleg, E-mail: oleg.mironov@uhn.ca, Sharma, Ashwani K., E-mail: Ashwani-Sharma@URMC.Rochester.edu, & Foster, Thomas H., E-mail: thomas.foster@rochester.edu. Indwelling Stent Embedded with Light-Emitting Diodes for Photodynamic Therapy of Malignant Biliary Obstruction. United States. doi:10.1007/S00270-015-1241-X.
Baran, Timothy M., E-mail: timothy.baran@rochester.edu, Mironov, Oleg, E-mail: oleg.mironov@uhn.ca, Sharma, Ashwani K., E-mail: Ashwani-Sharma@URMC.Rochester.edu, and Foster, Thomas H., E-mail: thomas.foster@rochester.edu. Wed . "Indwelling Stent Embedded with Light-Emitting Diodes for Photodynamic Therapy of Malignant Biliary Obstruction". United States. doi:10.1007/S00270-015-1241-X.
@article{osti_22642519,
title = {Indwelling Stent Embedded with Light-Emitting Diodes for Photodynamic Therapy of Malignant Biliary Obstruction},
author = {Baran, Timothy M., E-mail: timothy.baran@rochester.edu and Mironov, Oleg, E-mail: oleg.mironov@uhn.ca and Sharma, Ashwani K., E-mail: Ashwani-Sharma@URMC.Rochester.edu and Foster, Thomas H., E-mail: thomas.foster@rochester.edu},
abstractNote = {PurposeWe describe the design and preliminary characterization of a stent incorporating light-emitting diodes (LEDs) for photodynamic therapy (PDT) of malignant biliary obstruction.MethodsA prototype was constructed with red (640 nm) LEDs embedded in a 14.5 French polyurethane tube. The device was evaluated for optical power and subjected to physical and electrical tests. PDT-induced reactive oxygen species were imaged in a gel phantom.ResultsThe stent functioned at a 2.5-cm bend radius and illuminated for 6 months in saline. No stray currents were detected, and it was cool after 30 minutes of operation. Optical power of 5–15 mW is applicable to PDT. Imaging of a reactive oxygen indicator showed LED-stent activation of photosensitizer.ConclusionsThe results motivate biological testing and design optimization.},
doi = {10.1007/S00270-015-1241-X},
journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 6,
volume = 39,
place = {United States},
year = {2016},
month = {6}
}