Comparative analysis of the effect of low-dimensional alumina structures on cell lines L929 and Neuro-2a
The paper presents the toxicity evaluation of nanostructures on the basis of alumina of different shape (nanofibers, nanoplates, nanosheets, nanosheet agglomerates) and with similar physical and chemical properties (particle size, specific surface area, phase composition, and zeta potential). The nanostructures were examined by transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), low-temperature nitrogen adsorption, and dynamic light scattering (DLS). The cytotoxicity of nanostructures was estimated using L929 fibroblast cells and Neuro-2a tumor cells. It has been found that the L929 cells are less subject to the influence of alumina nanoparticles than the Neuro-2a tumor cells. Probably, the differences in the proliferation activity of normal and tumor cells in contact with the synthesized nanostructures are due to a change in the pH of the cell microenvironment.
- OSTI ID:
- 22608273
- Journal Information:
- AIP Conference Proceedings, Journal Name: AIP Conference Proceedings Journal Issue: 1 Vol. 1760; ISSN APCPCS; ISSN 0094-243X
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ADSORPTION
ALUMINIUM OXIDES
EVALUATION
FIBROBLASTS
LIGHT SCATTERING
NANOFIBERS
NANOPARTICLES
NEOPLASMS
PARTICLE SIZE
PROLIFERATION
SCANNING ELECTRON MICROSCOPY
SPECIFIC SURFACE AREA
SURFACES
TOXICITY
TRANSMISSION
TRANSMISSION ELECTRON MICROSCOPY
TUMOR CELLS
X-RAY DIFFRACTION