Effect of low-dimensional alumina structures on viability of L 929 cells

Journal Article · Tue Oct 27 00:00:00 EDT 2015 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.4932744· OSTI ID:22492523

In the study, we estimated the cytotoxicity of alumina nanoparticles differing in shape (nanofibers, nanoplates, nanosheets, agglomerates of nanosheets) and close in physicochemical properties (particle size, specific surface area, phase composition, and zeta potential). The alumina structures were characterized using transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD) data, low-temperature nitrogen adsorption, and dynamic light scattering (DLS). The cytotoxicity was estimated on fibroblast cells of the L929 line. It was found that a more adverse effect on the cells was exerted by alumina nanofibers and nanosheets. The action of nanosheets on the cells was inhibitory and was of about the same level, irrespective of the observation period. The effect of alumina nanosheet agglomerates and nanoplates on the cell proliferation was weak even at an exposure time of 72 h.

• OSTI ID: 22492523
• Journal Information: AIP Conference Proceedings, Journal Name: AIP Conference Proceedings Journal Issue: 1 Vol. 1683; ISSN APCPCS; ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
ADSORPTION
ALUMINIUM OXIDES
CELL PROLIFERATION
FIBROBLASTS
LIGHT SCATTERING
NANOFIBERS
NANOPARTICLES
NITROGEN
PARTICLE SIZE
SCANNING ELECTRON MICROSCOPY
SHEETS
SPECIFIC SURFACE AREA
TEMPERATURE RANGE 0065-0273 K
TOXICITY
TRANSMISSION ELECTRON MICROSCOPY
VIABILITY
X-RAY DIFFRACTION