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Title: Radiopharmaceuticals for SPECT cancer detection

Abstract

The purpose of the study was to assess the efficacy of single photon emission computed tomography (SPECT) with {sup 199}Tl and {sup 99}mTc-MIBI in the detection of breast, laryngeal and hypopharyngeal cancers. A total of 220 patients were included into the study: 120 patients with breast lesions (100 patients with breast cancer and 20 patients with benign breast tumors) and 100 patients with laryngeal/hypopharyngeal diseases (80 patients with laryngeal/hypopharyngeal cancer and 20 patients with benign laryngeal/hypopharyngeal lesions). No abnormal {sup 199}Tl uptake was seen in all patients with benign breast and laryngeal lesions, indicating a 100% specificity of {sup 199}Tl SPECT. In the breast cancer patients, the increased {sup 199}Tl uptake in the breast was visualized in 94.8% patients, {sup 99m}Tc-MIBI—in 93.4% patients. The increased {sup 199}Tl uptake in axillary lymph nodes was detected in 60% patients, and {sup 99m}Tc-MIBI—in 93.1% patients. In patients with laryngeal/hypopharyngeal cancer, the sensitivity of SPECT with {sup 199}Tl and {sup 99m}Tc-MIBI was 95%. The {sup 199}Tl SPECT sensitivity in identification of regional lymph node metastases in the patients with laryngeal/hypopharyngeal cancer was 75% and the {sup 99m}Tc-MIBI SPECT sensitivity was 17%. The data obtained showed that SPECT with {sup 199}Tl and {sup 99m}Tc-MIBI canmore » be used as one of the additional imaging methods in detection of tumors.« less

Authors:
; ; ;  [1];  [2]; ;  [3]; ;  [1]
  1. Tomsk Cancer Research Institute, Kooperativny Street 5, Tomsk, 634050 (Russian Federation)
  2. (Russian Federation)
  3. Tomsk Polytechnic University, Lenin Avenue 30, Tomsk, 634050 (Russian Federation)
Publication Date:
OSTI Identifier:
22608270
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Conference Proceedings; Journal Volume: 1760; Journal Issue: 1; Conference: PC'16: International conference on physics of cancer: Interdisciplinary problems and clinical applications 2016, Tomsk (Russian Federation), 22-25 Mar 2016; Other Information: (c) 2016 Author(s); Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BIOMEDICAL RADIOGRAPHY; DETECTION; LYMPH; LYMPH NODES; MAMMARY GLANDS; METASTASES; NEOPLASMS; PATIENTS; PHOTON EMISSION; PHOTONS; RADIOPHARMACEUTICALS; SENSITIVITY; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; SPECIFICITY; TECHNETIUM 99; THALLIUM 199

Citation Formats

Chernov, V. I., E-mail: chernov@oncology.tomsk.ru, Medvedeva, A. A., E-mail: tickayaAA@oncology.tomsk.ru, Zelchan, R. V., E-mail: r.zelchan@yandex.ru, Sinilkin, I. G., E-mail: sinilkinig@oncology.tomsk.ru, Tomsk Polytechnic University, Lenin Avenue 30, Tomsk, 634050, Stasyuk, E. S., Larionova, L. A., Slonimskaya, E. M., and Choynzonov, E. L. Radiopharmaceuticals for SPECT cancer detection. United States: N. p., 2016. Web. doi:10.1063/1.4960230.
Chernov, V. I., E-mail: chernov@oncology.tomsk.ru, Medvedeva, A. A., E-mail: tickayaAA@oncology.tomsk.ru, Zelchan, R. V., E-mail: r.zelchan@yandex.ru, Sinilkin, I. G., E-mail: sinilkinig@oncology.tomsk.ru, Tomsk Polytechnic University, Lenin Avenue 30, Tomsk, 634050, Stasyuk, E. S., Larionova, L. A., Slonimskaya, E. M., & Choynzonov, E. L. Radiopharmaceuticals for SPECT cancer detection. United States. doi:10.1063/1.4960230.
Chernov, V. I., E-mail: chernov@oncology.tomsk.ru, Medvedeva, A. A., E-mail: tickayaAA@oncology.tomsk.ru, Zelchan, R. V., E-mail: r.zelchan@yandex.ru, Sinilkin, I. G., E-mail: sinilkinig@oncology.tomsk.ru, Tomsk Polytechnic University, Lenin Avenue 30, Tomsk, 634050, Stasyuk, E. S., Larionova, L. A., Slonimskaya, E. M., and Choynzonov, E. L. Tue . "Radiopharmaceuticals for SPECT cancer detection". United States. doi:10.1063/1.4960230.
@article{osti_22608270,
title = {Radiopharmaceuticals for SPECT cancer detection},
author = {Chernov, V. I., E-mail: chernov@oncology.tomsk.ru and Medvedeva, A. A., E-mail: tickayaAA@oncology.tomsk.ru and Zelchan, R. V., E-mail: r.zelchan@yandex.ru and Sinilkin, I. G., E-mail: sinilkinig@oncology.tomsk.ru and Tomsk Polytechnic University, Lenin Avenue 30, Tomsk, 634050 and Stasyuk, E. S. and Larionova, L. A. and Slonimskaya, E. M. and Choynzonov, E. L.},
abstractNote = {The purpose of the study was to assess the efficacy of single photon emission computed tomography (SPECT) with {sup 199}Tl and {sup 99}mTc-MIBI in the detection of breast, laryngeal and hypopharyngeal cancers. A total of 220 patients were included into the study: 120 patients with breast lesions (100 patients with breast cancer and 20 patients with benign breast tumors) and 100 patients with laryngeal/hypopharyngeal diseases (80 patients with laryngeal/hypopharyngeal cancer and 20 patients with benign laryngeal/hypopharyngeal lesions). No abnormal {sup 199}Tl uptake was seen in all patients with benign breast and laryngeal lesions, indicating a 100% specificity of {sup 199}Tl SPECT. In the breast cancer patients, the increased {sup 199}Tl uptake in the breast was visualized in 94.8% patients, {sup 99m}Tc-MIBI—in 93.4% patients. The increased {sup 199}Tl uptake in axillary lymph nodes was detected in 60% patients, and {sup 99m}Tc-MIBI—in 93.1% patients. In patients with laryngeal/hypopharyngeal cancer, the sensitivity of SPECT with {sup 199}Tl and {sup 99m}Tc-MIBI was 95%. The {sup 199}Tl SPECT sensitivity in identification of regional lymph node metastases in the patients with laryngeal/hypopharyngeal cancer was 75% and the {sup 99m}Tc-MIBI SPECT sensitivity was 17%. The data obtained showed that SPECT with {sup 199}Tl and {sup 99m}Tc-MIBI can be used as one of the additional imaging methods in detection of tumors.},
doi = {10.1063/1.4960230},
journal = {AIP Conference Proceedings},
number = 1,
volume = 1760,
place = {United States},
year = {Tue Aug 02 00:00:00 EDT 2016},
month = {Tue Aug 02 00:00:00 EDT 2016}
}