Evaluation of malignant pulmonary lesions with Tc-99m-MIBI
- Osaka Medical College (Japan); and others
Tc-99m-MIBI (MIBI) SPECT was performed in 20 patients with suspected malignant pulmonary lesions and its usefulness in detection results and judgment of treatment effects in irradiation and chemotherapy were examined. The study population consisted of 18 cases of primary lung cancer, 1 case of malignant lymphoma, 1 case of pulmonary tuberculoma. We set the region of interest (ROIs) in the area with abnormal MIBI uptake and in the contralateral normal lung on a transverse image, and obtained uptake ratios of the lesion to the contralateral normal lung on early scan (early ratio) and that of delayed scan (delayed ratio). An increased uptake was obtained in all of 19 malignant lung lesions including 1 malignant lymphoma. The minimum diameter of the tumor was 1.0{sup x} 0.5 cm. The early ratio and delayed ratio was 1.72{plus_minus}0.49 and 1.95{plus_minus}0.69 (mean{plus_minus}S.D.) for the pre-treatment malignant lesions. At the delayed image MIBI washout in the malignant lesions was poor, however tuberculoma showed strong washout. Its early ratio and delayed ratio was 1.42 and 1.29. The early ratio and delayed ratio for post-treatment malignant lesions was 1.79{plus_minus}0.89 and 1.93{plus_minus}0.72. When the patients were same patients at pre and post-treatment, the early ratio had significantly decreased. (Before 1.78{plus_minus}0.29 After 1.35{plus_minus}0.37, p<0.05). And the accumulation in the malignant tumor on early image correlated with the tumor vascularity of bronchoarteriography. MIBI showed high clearance from the blood pool, so we could easily recognize the hilar and mediastinal lymph nodes metastases. We conclude that MIBI SPECT has excellent detectability for the malignant lesions and it seems to be useful for the judgment of treatment effects.
- OSTI ID:
- 198084
- Report Number(s):
- CONF-940605--
- Journal Information:
- Journal of Nuclear Medicine, Journal Name: Journal of Nuclear Medicine Journal Issue: Suppl.5 Vol. 35; ISSN JNMEAQ; ISSN 0161-5505
- Country of Publication:
- United States
- Language:
- English
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