Prenatal exposure to environmental contaminants and body composition at age 7–9 years

Journal Article · Tue Jul 15 04:00:00 EDT 2014 · Environmental Research

DOI:https://doi.org/10.1016/J.ENVRES.2014.03.019· OSTI ID:22447520

Delvaux, Immle; Van Cauwenberghe, Jolijn ^[1]; Den Hond, Elly; Schoeters, Greet; Govarts, Eva ^[2]; Nelen, Vera ^[3]; Baeyens, Willy ^[4]; Van Larebeke, Nicolas ^[5]; Sioen, Isabelle ^[1]

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1. Department of Public Health, Ghent University, UZ 2 Blok A, De Pintelaan 185, 9000 Ghent (Belgium)
2. Flemish Institute for Technological Research (VITO), Environmental Risk and Health, Boeretang 200, 2400 Mol (Belgium)
3. Department of Health, Provincial Institute for Hygiene, Kronenburgstraat 45, 2000 Antwerp (Belgium)
4. Department of Analytical and Environmental Chemistry, Free University of Brussels, Pleinlaan 2, 1050 Elsene (Belgium)
5. Department of Radiotherapy and Nuclear Medicine, Ghent University, De Pintelaan 185, 9000 Ghent (Belgium)

The study aim was to investigate the association between prenatal exposure to endocrine disrupting chemicals (EDCs) and the body composition of 7 to 9 year old Flemish children. The subjects were 114 Flemish children (50% boys) that took part in the first Flemish Environment and Health Study (2002–2006). Cadmium, PCBs, dioxins, p,p′-DDE and HCB were analysed in cord blood/plasma. When the child reached 7–9 years, height, weight, waist circumference and skinfolds were measured. Significant associations between prenatal exposure to EDCs and indicators of body composition were only found in girls. After adjustment for confounders and covariates, a significant negative association was found in girls between prenatal cadmium exposure and weight, BMI and waist circumference (indicator of abdominal fat) and the sum of four skinfolds (indicator of subcutaneous fat). In contrast, a significant positive association (after adjustment for confounders/covariates) was found between prenatal p,p′-DDE exposure and waist circumference as well as waist/height ratio in girls (indicators of abdominal fat). No significant associations were found for prenatal PCBs, dioxins and HCB exposure after adjustment for confounders/covariates. This study suggests a positive association between prenatal p,p′-DDE exposure and indicators of abdominal fat and a negative association between prenatal cadmium exposure and indicators of both abdominal as well as subcutaneous fat in girls between 7 and 9 years old. - Highlights: • Associations between prenatal contaminant exposure and anthropometrics in children. • Significant association only found in girls. • No significant associations found for prenatal PCBs, dioxins and HCB exposure. • Girls: negative association between cadmium and abdominal and subcutaneous fat. • Girls: positive association between p,p′-DDE and indicators of abdominal fat.

• OSTI ID: 22447520
• Journal Information: Environmental Research, Journal Name: Environmental Research Vol. 132; ISSN ENVRAL; ISSN 0013-9351
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
ADMINISTRATIVE PROCEDURES
BLOOD PLASMA
BODY COMPOSITION
CADMIUM
CHILDREN
DETECTION
DIOXIN
ENVIRONMENT
FATS
GROWTH
HEIGHT
INDEXES
INDICATORS
MASS
POLYCHLORINATED BIPHENYLS
PRENATAL EXPOSURE
WEIGHT