Prenatal dichlorodiphenyldichloroethylene (DDE) exposure and child growth during the first year of life

Journal Article · Wed Feb 15 04:00:00 EST 2012 · Environmental Research

DOI:https://doi.org/10.1016/J.ENVRES.2011.12.002· OSTI ID:22156258

Garced, Sheyla ^[1]; Torres-Sanchez, Luisa ^[2]; Claudio, Luz ^[1]; Lopez-Carrillo, Lizbeth ^[2]

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1. Department of Preventive Medicine, Mount Sinai School of Medicine, International Training and Research in Environmental and Occupational Health Program, 17 E 102nd Street, CAM Building, 3 West, One Gustave L. Levy Place, Box 1057, New York, NY 10029 (United States)
2. National Institute of Public Health, Av. Universidad 655, Col. Sta Maria Ahuacatitlan, C.P. 62100 Cuernavaca, Morelos (Mexico)

Background: Due to its long-term persistence in the environment and its ability to cross the placental barrier, prenatal p,p Prime -dichlorodiphenyldichloroethene (DDE) exposure continues to be a public health concern. This study aimed to evaluate the association between prenatal DDE exposure and child growth, at birth and during the first year of life. Methods: 253 pregnant women were recruited between January 2001 and June 2005 in a prospective cohort in Morelos, Mexico. Serum levels of DDE were measured during each trimester of pregnancy by gas chromatography with an electron capture detector. Using the generalized mixed-effects models, the association between DDE and child growth parameters (weight-for-age, length-for-age, weight-for-length, BMI-for-age and head circumference-for-age Z-scores) from birth to 1 year of age was assessed. Maternal dietary intake was considered as covariable among others. Results: DDE levels were 6.3{+-}2.8 ng/mL (first trimester), 6.6{+-}2.9 ng/mL (second trimester), and 7.6{+-}2.9 ng/mL (third trimester). After adjusting for potential confounder variables, no significant associations were observed with prenatal DDE exposure and each of the selected parameters. Conclusions: Our results show no evidence of an association between prenatal DDE exposure and child growth during the first year of life.

• OSTI ID: 22156258
• Journal Information: Environmental Research, Journal Name: Environmental Research Vol. 113; ISSN ENVRAL; ISSN 0013-9351
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
60 APPLIED LIFE SCIENCES
CHILDREN
ELECTRON-CAPTURE DETECTORS
GAS CHROMATOGRAPHY
GROWTH
ORGANIC CHLORINE COMPOUNDS