Generation of drugs coated iron nanoparticles through high energy ball milling
- Department of Metallurgical and Materials Engineering, Indian Institute of Technology Madras, Chennai 600036 (India)
- Defence Metallurgical Research Laboratory, Hyderabad 500058 (India)
- Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600036 (India)
The iron nanoparticles coated with oleic acid and drugs such as folic acid/Amoxicillin were synthesized by high energy ball milling and characterized by X-ray diffraction, Transmission electron microscope, zeta potential, dynamic light scattering, Fourier Transform Infra red (FT-IR) measurements, and thermo gravimetric analysis (TGA). FT-IR and TGA measurements show good adsorption of drugs on oleic acid coated nanoparticles. Magnetic measurements indicate that saturation magnetization is larger for amoxicillin coated particles compared to folic acid coated particles. The biocompatibility of the magnetic nanoparticles prepared was evaluated by in vitro cytotoxicity assay using L929 cells as model cells.
- OSTI ID:
- 22271128
- Journal Information:
- Journal of Applied Physics, Vol. 115, Issue 12; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); ISSN 0021-8979
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
SUPERCONDUCTIVITY AND SUPERFLUIDITY
77 NANOSCIENCE AND NANOTECHNOLOGY
ADSORPTION
COMPARATIVE EVALUATIONS
FOLIC ACID
FOURIER TRANSFORMATION
INFRARED SPECTRA
IRON
LIGHT SCATTERING
MAGNETIZATION
MILLING
NANOSTRUCTURES
OLEIC ACID
PARTICLES
THERMAL GRAVIMETRIC ANALYSIS
TRANSMISSION ELECTRON MICROSCOPY
X-RAY DIFFRACTION