Electron spin resonance studies on reduction process of nitroxyl spin radicals used in molecular imaging

Journal Article · Thu Apr 24 04:00:00 EDT 2014 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.4872955· OSTI ID:22269308

Dhas, M. Kumara; Benial, A. Milton Franklin, ^[1]; Jawahar, A. ^[2]

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1. Department of Physics, NMSSVN College, Nagamalai, Madurai-625019, Tamilnadu (India)
2. Department of Chemistry, NMSSVN College, Nagamalai, Madurai-625019, Tamilnadu (India)

The Electron spin resonance studies on the reduction process of nitroxyl spin probes were carried out for 1mM {sup 14}N labeled nitroxyl radicals in pure water and 1 mM concentration of ascorbic acid as a function of time. The electron spin resonance parameters such as signal intensity ratio, line width, g-value, hyperfine coupling constant and rotational correlation time were determined. The half life time was estimated for 1mM {sup 14}N labeled nitroxyl radicals in 1 mM concentration of ascorbic acid. The ESR study reveals that the TEMPONE has narrowest line width and fast tumbling motion compared with TEMPO and TEMPOL. From the results, TEMPONE has long half life time and high stability compared with TEMPO and TEMPOL radical. Therefore, this study reveals that the TEMPONE radical can act as a good redox sensitive spin probe for molecular imaging.

• OSTI ID: 22269308
• Journal Information: AIP Conference Proceedings, Journal Name: AIP Conference Proceedings Journal Issue: 1 Vol. 1591; ISSN 0094-243X; ISSN APCPCS
• Country of Publication: United States
• Language: English

Related Subjects

75 CONDENSED MATTER PHYSICS
SUPERCONDUCTIVITY AND SUPERFLUIDITY
ASCORBIC ACID
COUPLING CONSTANTS
ELECTRON SPIN RESONANCE
LINE WIDTHS
NITROGEN 14
NITROXYL RADICALS
PROBES
SPIN
STABILITY
TIME DEPENDENCE