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Title: LabVIEW-based control software for para-hydrogen induced polarization instrumentation

Abstract

The elucidation of cell metabolic mechanisms is the modern underpinning of the diagnosis, treatment, and in some cases the prevention of disease. Para-Hydrogen induced polarization (PHIP) enhances magnetic resonance imaging (MRI) signals over 10 000 fold, allowing for the MRI of cell metabolic mechanisms. This signal enhancement is the result of hyperpolarizing endogenous substances used as contrast agents during imaging. PHIP instrumentation hyperpolarizes Carbon-13 ({sup 13}C) based substances using a process requiring control of a number of factors: chemical reaction timing, gas flow, monitoring of a static magnetic field (B{sub o}), radio frequency (RF) irradiation timing, reaction temperature, and gas pressures. Current PHIP instruments manually control the hyperpolarization process resulting in the lack of the precise control of factors listed above, resulting in non-reproducible results. We discuss the design and implementation of a LabVIEW based computer program that automatically and precisely controls the delivery and manipulation of gases and samples, monitoring gas pressures, environmental temperature, and RF sample irradiation. We show that the automated control over the hyperpolarization process results in the hyperpolarization of hydroxyethylpropionate. The implementation of this software provides the fast prototyping of PHIP instrumentation for the evaluation of a myriad of {sup 13}C based endogenous contrast agents usedmore » in molecular imaging.« less

Authors:
; ;  [1];  [2];  [3];  [4];  [5];  [6]
  1. Department of Bioengineering, University of California, Los Angeles, California 91791 (United States)
  2. (United States)
  3. Ectron Corp, San Diego, California 92111 (United States)
  4. Harris Corp, San Diego, California 92154 (United States)
  5. Department of Biology, San Diego State University, San Diego, California 92182 (United States)
  6. BIRI, Cedars Sinai Medical Center, West Hollywood, California 90048 (United States)
Publication Date:
OSTI Identifier:
22254937
Resource Type:
Journal Article
Resource Relation:
Journal Name: Review of Scientific Instruments; Journal Volume: 85; Journal Issue: 4; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; AMBIENT TEMPERATURE; CARBON 13; CHEMICAL REACTIONS; COMPUTER CODES; CONTRAST MEDIA; GAS FLOW; MAGNETIC FIELDS; NMR IMAGING; POLARIZATION; RADIOWAVE RADIATION

Citation Formats

Agraz, Jose, E-mail: joseagraz@ucla.edu, Grunfeld, Alexander, Li, Debiao, BIRI, Cedars Sinai Medical Center, West Hollywood, California 90048, Cunningham, Karl, Willey, Cindy, Pozos, Robert, and Wagner, Shawn. LabVIEW-based control software for para-hydrogen induced polarization instrumentation. United States: N. p., 2014. Web. doi:10.1063/1.4870797.
Agraz, Jose, E-mail: joseagraz@ucla.edu, Grunfeld, Alexander, Li, Debiao, BIRI, Cedars Sinai Medical Center, West Hollywood, California 90048, Cunningham, Karl, Willey, Cindy, Pozos, Robert, & Wagner, Shawn. LabVIEW-based control software for para-hydrogen induced polarization instrumentation. United States. doi:10.1063/1.4870797.
Agraz, Jose, E-mail: joseagraz@ucla.edu, Grunfeld, Alexander, Li, Debiao, BIRI, Cedars Sinai Medical Center, West Hollywood, California 90048, Cunningham, Karl, Willey, Cindy, Pozos, Robert, and Wagner, Shawn. 2014. "LabVIEW-based control software for para-hydrogen induced polarization instrumentation". United States. doi:10.1063/1.4870797.
@article{osti_22254937,
title = {LabVIEW-based control software for para-hydrogen induced polarization instrumentation},
author = {Agraz, Jose, E-mail: joseagraz@ucla.edu and Grunfeld, Alexander and Li, Debiao and BIRI, Cedars Sinai Medical Center, West Hollywood, California 90048 and Cunningham, Karl and Willey, Cindy and Pozos, Robert and Wagner, Shawn},
abstractNote = {The elucidation of cell metabolic mechanisms is the modern underpinning of the diagnosis, treatment, and in some cases the prevention of disease. Para-Hydrogen induced polarization (PHIP) enhances magnetic resonance imaging (MRI) signals over 10 000 fold, allowing for the MRI of cell metabolic mechanisms. This signal enhancement is the result of hyperpolarizing endogenous substances used as contrast agents during imaging. PHIP instrumentation hyperpolarizes Carbon-13 ({sup 13}C) based substances using a process requiring control of a number of factors: chemical reaction timing, gas flow, monitoring of a static magnetic field (B{sub o}), radio frequency (RF) irradiation timing, reaction temperature, and gas pressures. Current PHIP instruments manually control the hyperpolarization process resulting in the lack of the precise control of factors listed above, resulting in non-reproducible results. We discuss the design and implementation of a LabVIEW based computer program that automatically and precisely controls the delivery and manipulation of gases and samples, monitoring gas pressures, environmental temperature, and RF sample irradiation. We show that the automated control over the hyperpolarization process results in the hyperpolarization of hydroxyethylpropionate. The implementation of this software provides the fast prototyping of PHIP instrumentation for the evaluation of a myriad of {sup 13}C based endogenous contrast agents used in molecular imaging.},
doi = {10.1063/1.4870797},
journal = {Review of Scientific Instruments},
number = 4,
volume = 85,
place = {United States},
year = 2014,
month = 4
}
  • We demonstrate the creation and observation ofpara-hydrogen-induced polarization in heterogeneous hydrogenationreactions. Wilkinson's catalyst, RhCl(PPh3)3, supported on eithermodified silica gel or a polymer, is shown to hydrogenate styrene intoethylbenzene and to produce enhanced spin polarizations, observed throughNMR, when the reaction was performed with H2 gas enriched in the paraspinisomer. Furthermore, gaseous phase para-hydrogenation of propylene topropane with two catalysts, the Wilkinson's catalyst supported onmodified silica gel and Rh(cod)(sulfos) (cod = cycloocta-1,5-diene;sulfos) - O3S(C6H4)CH2C(CH2PPh2)3) supported on silica gel, demonstratesheterogeneous catalytic conversion resulting in large spin polarizations.These experiments serve as a direct verification of the mechanism ofheterogeneous hydrogenation reactions involving immobilized metalcomplexes andmore » can be potentially developed into a practical tool forproducing catalyst-free fluids with highly polarized nuclear spins for abroad range of hyperpolarized NMR and MRI applications.« less
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