Carbon-13 Radiofrequency Amplification by Stimulated Emission of Radiation of the Hyperpolarized Ketone and Hemiketal Forms of Allyl [1-13C]Pyruvate

Nantogma, Shiraz; de Maissin, Henri; Adelabu, Isaiah; Abdurraheem, Abubakar; Nelson, Christopher; Chukanov, Nikita V.; Salnikov, Oleg G.; Koptyug, Igor V.; Lehmkuhl, Sören; Schmidt, Andreas B.; Appelt, Stephan; Theis, Thomas; Chekmenev, Eduard Y.

doi:10.1021/acssensors.3c02075

Carbon-13 Radiofrequency Amplification by Stimulated Emission of Radiation of the Hyperpolarized Ketone and Hemiketal Forms of Allyl [1-¹³C]Pyruvate

Journal Article · Tue Jan 09 23:00:00 EST 2024 · ACS Sensors

DOI:https://doi.org/10.1021/acssensors.3c02075· OSTI ID:2341454

Nantogma, Shiraz ^[1]; de Maissin, Henri ^[2]; ^[3]; Abdurraheem, Abubakar ^[3]; Nelson, Christopher ^[4]; Chukanov, Nikita V. ^[5]; ^[5]; ^[6]; ^[7]; ^[8]; Appelt, Stephan ^[9]; ^[4]; ^[10]

Wayne State University, Detroit, MI (United States); North Carolina State University
University of Freiburg (Germany); German Cancer Consortium (DKTK), Heidelberg (Germany)
Wayne State University, Detroit, MI (United States)
North Carolina State University, Raleigh, NC (United States)
International Tomography Center SB RAS, Novosibirsk (Russia)
International Tomography Center SB RAS, Novosibirsk (Russia); Boreskov Institute of Catalysis SB RAS, Novosibirsk (Russia)
Karlsruhe Institute of Technology (Germany)
Wayne State University, Detroit, MI (United States); University of Freiburg (Germany); German Cancer Consortium (DKTK), Heidelberg (Germany)
RWTH Aachen University (Germany); Forschungszentrum Jülich GmbH (Germany)
Russian Academy of Sciences, Moscow (Russia)

¹³C hyperpolarized pyruvate is an emerging MRI contrast agent for sensing molecular events in cancer and other diseases with aberrant metabolic pathways. This metabolic contrast agent can be produced via several hyperpolarization techniques. Despite remarkable success in research settings, widespread clinical adoption faces substantial roadblocks because the current sensing technology utilized to sense this contrast agent requires the excitation of ¹³C nuclear spins that also need to be synchronized with MRI field gradient pulses. Here, we demonstrate sensing of hyperpolarized allyl [1-¹³C]pyruvate via the stimulated emission of radiation that mitigates the requirements currently blocking broader adoption. Specifically, ¹³C Radiofrequency Amplification by Stimulated Emission of Radiation (¹³C RASER) was obtained after pairwise addition of parahydrogen to a pyruvate precursor, detected in a commercial inductive detector with a quality factor (Q) of 32 for sample concentrations as low as 0.125 M with ¹³C polarization of 4%. Moreover, parahydrogen-induced polarization allowed for the preparation of a mixture of ketone and hemiketal forms of hyperpolarized allyl [1-¹³C]pyruvate, which are separated by 10 ppm in ¹³C NMR spectra. This is a good model system to study the simultaneous ¹³C RASER signals of multiple ¹³C species. This system models the metabolic production of hyperpolarized [1-¹³C]lactate from hyperpolarized [1-¹³C]pyruvate, which has a similar chemical shift difference. Our results show that ¹³C RASER signals can be obtained from both species simultaneously when the emission threshold is exceeded for both species. On the other hand, when the emission threshold is exceeded only for one of the hyperpolarized species, ¹³C stimulated emission is confined to this species only, therefore enabling the background-free detection of individual hyperpolarized ¹³C signals. Furthermore, the reported results pave the way to novel sensing approaches of ¹³C hyperpolarized pyruvate, potentially unlocking hyperpolarized ¹³C MRI on virtually any MRI system–an attractive vision for the future molecular imaging and diagnostics.

View Accepted Manuscript (DOE)

Research Organization:: North Carolina State University, Raleigh, NC (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER); National Institutes of Health (NIH); National Science Foundation (NSF)

Grant/Contract Number:: SC0023334

OSTI ID:: 2341454

Journal Information:: ACS Sensors, Journal Name: ACS Sensors Journal Issue: 2 Vol. 9; ISSN 2379-3694

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

References (78)

Parahydrogen‐Polarized [1‐¹³C]Pyruvate for Reliable and Fast Preclinical Metabolic Magnetic Resonance Imaging Nagel, Luca; Gierse, Martin; Gottwald, Wolfgang Advanced Science, Vol. 10, Issue 30 https://doi.org/10.1002/advs.202303441	journal	August 2023
Parahydrogen‐Induced Radio Amplification by Stimulated Emission of Radiation Joalland, Baptiste; Ariyasingha, Nuwandi M.; Lehmkuhl, Sören Angewandte Chemie, Vol. 132, Issue 22 https://doi.org/10.1002/ange.201916597	journal	March 2020
Facing and Overcoming Sensitivity Challenges in Biomolecular NMR Spectroscopy Ardenkjaer-Larsen, Jan-Henrik; Boebinger, Gregory S.; Comment, Arnaud Angewandte Chemie International Edition, Vol. 54, Issue 32 https://doi.org/10.1002/anie.201410653	journal	July 2015
Parahydrogen-Based Hyperpolarization for Biomedicine Hövener, Jan-Bernd; Pravdivtsev, Andrey N.; Kidd, Bryce Angewandte Chemie International Edition, Vol. 57, Issue 35 https://doi.org/10.1002/anie.201711842	journal	August 2018
Hyperpolarising Pyruvate through Signal Amplification by Reversible Exchange (SABRE) Iali, Wissam; Roy, Soumya S.; Tickner, Ben J. Angewandte Chemie International Edition, Vol. 58, Issue 30 https://doi.org/10.1002/anie.201905483	journal	July 2019
Enabling Clinical Technologies for Hyperpolarized ¹²⁹Xenon Magnetic Resonance Imaging and Spectroscopy Khan, Alixander S.; Harvey, Rebecca L.; Birchall, Jonathan R. Angewandte Chemie International Edition, Vol. 60, Issue 41 https://doi.org/10.1002/anie.202015200	journal	June 2021
Background‐Free Proton NMR Spectroscopy with Radiofrequency Amplification by Stimulated Emission Radiation Joalland, Baptiste; Theis, Thomas; Appelt, Stephan Angewandte Chemie International Edition, Vol. 60, Issue 50 https://doi.org/10.1002/anie.202108939	journal	October 2021
Parahydrogen‐Induced Carbon‐13 Radiofrequency Amplification by Stimulated Emission of Radiation Nelson, Christopher; Schmidt, Andreas B.; Adelabu, Isaiah Angewandte Chemie International Edition, Vol. 62, Issue 5 https://doi.org/10.1002/anie.202215678	journal	December 2022
In Vivo Metabolic Imaging of [1‐¹³C]Pyruvate‐d₃ Hyperpolarized By Reversible Exchange With Parahydrogen** de Maissin, Henri; Groß, Philipp R.; Mohiuddin, Obaid Angewandte Chemie International Edition, Vol. 62, Issue 36 https://doi.org/10.1002/anie.202306654	journal	July 2023
Hyperpolarized NMR Spectroscopy: d -DNP, PHIP, and SABRE Techniques Kovtunov, Kirill V.; Pokochueva, Ekaterina V.; Salnikov, Oleg G. Chemistry - An Asian Journal, Vol. 13, Issue 15 https://doi.org/10.1002/asia.201800551	journal	July 2018
NMR Hyperpolarization Techniques for Biomedicine Nikolaou, Panayiotis; Goodson, Boyd M.; Chekmenev, Eduard Y. Chemistry – A European Journal, Vol. 21, Issue 8 https://doi.org/10.1002/chem.201405253	journal	December 2014
The Absence of Quadrupolar Nuclei Facilitates Efficient ¹³ C Hyperpolarization via Reversible Exchange with Parahydrogen Barskiy, Danila A.; Shchepin, Roman V.; Tanner, Christian P. N. ChemPhysChem, Vol. 18, Issue 12 https://doi.org/10.1002/cphc.201700416	journal	May 2017
Hyperpolarized ¹³ C Magnetic Resonance Imaging of Fumarate Metabolism by Parahydrogen‐induced Polarization: A Proof‐of‐Concept in vivo Study Stewart, Neil J.; Nakano, Hitomi; Sugai, Shuto ChemPhysChem, Vol. 22, Issue 10 https://doi.org/10.1002/cphc.202001038	journal	March 2021
A Versatile Compact Parahydrogen Membrane Reactor TomHon, Patrick M.; Han, Suyong; Lehmkuhl, Sören ChemPhysChem, Vol. 22, Issue 24 https://doi.org/10.1002/cphc.202100667	journal	October 2021
Order‐Unity ¹³C Nuclear Polarization of [1‐¹³C]Pyruvate in Seconds and the Interplay of Water and SABRE Enhancement Adelabu, Isaiah; TomHon, Patrick; Kabir, Mohammad S. H. ChemPhysChem, Vol. 23, Issue 2 https://doi.org/10.1002/cphc.202100839	journal	December 2021
Metabolic Tumor Imaging with Rapidly Signal‐Enhanced 1‐¹³C‐Pyruvate‐d₃ Hune, Theresa; Mamone, Salvatore; Schroeder, Henning ChemPhysChem, Vol. 24, Issue 2 https://doi.org/10.1002/cphc.202200615	journal	October 2022
The Steady‐State ALTADENA RASER Generates Continuous NMR Signals** Yang, Jing; Wang, Peng; Korvink, Jan G. ChemPhysChem, Vol. 24, Issue 14 https://doi.org/10.1002/cphc.202300204	journal	June 2023
Hyperpolarized ¹²⁹ Xe MRI of the human lung Mugler, John P.; Altes, Talissa A. Journal of Magnetic Resonance Imaging, Vol. 37, Issue 2 https://doi.org/10.1002/jmri.23844	journal	January 2013
Magnetic shielding of parahydrogen hyperpolarization experiments for the masses Joalland, Baptiste; Nantogma, Shiraz; Chowdhury, Md Raduanul H. Magnetic Resonance in Chemistry, Vol. 59, Issue 12 https://doi.org/10.1002/mrc.5167	journal	May 2021
Imaging considerations for in vivo ¹³C metabolic mapping using hyperpolarized ¹³C‐pyruvate Yen, Y‐F.; Kohler, S. J.; Chen, A. P. Magnetic Resonance in Medicine, Vol. 62, Issue 1 https://doi.org/10.1002/mrm.21987	journal	March 2009
Robust and high resolution hyperpolarized metabolic imaging of the rat heart at 7 t with 3d spectral‐spatial EPI Miller, Jack J.; Lau, Angus Z.; Teh, Irvin Magnetic Resonance in Medicine, Vol. 75, Issue 4 https://doi.org/10.1002/mrm.25730	journal	May 2015
Mapping of intracellular pH in the in vivo rodent heart using hyperpolarized [1‐13C]pyruvate Lau, Angus Z.; Miller, Jack J.; Tyler, Damian J. Magnetic Resonance in Medicine, Vol. 77, Issue 5 https://doi.org/10.1002/mrm.26260	journal	May 2016
Cryogen‐free dissolution dynamic nuclear polarization polarizer operating at 3.35 T, 6.70 T, and 10.1 T Ardenkjær‐Larsen, Jan Henrik; Bowen, Sean; Petersen, Jan Raagaard Magnetic Resonance in Medicine, Vol. 81, Issue 3 https://doi.org/10.1002/mrm.27537	journal	October 2018
A variable resolution approach for improved acquisition of hyperpolarized ¹³C metabolic MRI Gordon, Jeremy W.; Autry, Adam W.; Tang, Shuyu Magnetic Resonance in Medicine, Vol. 84, Issue 6 https://doi.org/10.1002/mrm.28421	journal	July 2020
NMR of hyperpolarised probes: NMR of hyperpolarised probes Mulder, Willem J. M.; McMahon, Michael T.; Nicolay, Klaas NMR in Biomedicine, Vol. 26, Issue 7 https://doi.org/10.1002/nbm.2873	journal	October 2012
Translational applications of hyperpolarized ³ He and ¹²⁹ Xe Walkup, Laura L.; Woods, Jason C. NMR in Biomedicine, Vol. 27, Issue 12 https://doi.org/10.1002/nbm.3151	journal	June 2014
The signal-to-noise ratio of the nuclear magnetic resonance experiment Hoult, D. I.; Richards, R. E. Journal of Magnetic Resonance (1969), Vol. 24, Issue 1, p. 71-85 https://doi.org/10.1016/0022-2364(76)90233-X	journal	October 1976
PET/CT with 11C-choline and 18F-FDG in patients with elevated PSA after radical treatment of a prostate cancer García, J. R.; Soler, M.; Blanch, M. A. Revista Española de Medicina Nuclear (English Edition), Vol. 28, Issue 3 https://doi.org/10.1016/S1578-200X(09)70016-6	journal	May 2009
Metabolic Imaging and Other Applications of Hyperpolarized 13C1 Golman, Klaes; Petersson, J. Stefan Academic Radiology, Vol. 13, Issue 8 https://doi.org/10.1016/j.acra.2006.06.001	journal	August 2006
Oxidative phosphorylation in cancer cells Solaini, Giancarlo; Sgarbi, Gianluca; Baracca, Alessandra Biochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1807, Issue 6 https://doi.org/10.1016/j.bbabio.2010.09.003	journal	June 2011
Transfer of para-hydrogen spin order into polarization by diabatic field cycling Jóhannesson, Haukur; Axelsson, Oskar; Karlsson, Magnus Comptes Rendus Physique, Vol. 5, Issue 3 https://doi.org/10.1016/j.crhy.2004.02.001	journal	April 2004
Xenon for NMR biosensing – Inert but alert Schröder, Leif Physica Medica, Vol. 29, Issue 1 https://doi.org/10.1016/j.ejmp.2011.11.001	journal	January 2013
On the present and future of dissolution-DNP Ardenkjaer-Larsen, Jan Henrik Journal of Magnetic Resonance, Vol. 264 https://doi.org/10.1016/j.jmr.2016.01.015	journal	March 2016
Using a local low rank plus sparse reconstruction to accelerate dynamic hyperpolarized 13 C imaging using the bSSFP sequence Milshteyn, Eugene; von Morze, Cornelius; Reed, Galen D. Journal of Magnetic Resonance, Vol. 290 https://doi.org/10.1016/j.jmr.2018.03.006	journal	May 2018
First hyperpolarized [2-13C]pyruvate MR studies of human brain metabolism Chung, Brian T.; Chen, Hsin-Yu; Gordon, Jeremy Journal of Magnetic Resonance, Vol. 309 https://doi.org/10.1016/j.jmr.2019.106617	journal	December 2019
SABRE and PHIP pumped RASER and the route to chaos Appelt, Stephan; Lehmkuhl, Sören; Fleischer, Simon Journal of Magnetic Resonance, Vol. 322 https://doi.org/10.1016/j.jmr.2020.106815	journal	January 2021
Facile hyperpolarization chemistry for molecular imaging and metabolic tracking of [1–13C]pyruvate in vivo MacCulloch, Keilian; Browning, Austin; Guarin Bedoya, David O. Journal of Magnetic Resonance Open, Vol. 16-17 https://doi.org/10.1016/j.jmro.2023.100129	journal	December 2023
Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology Kurhanewicz, John; Vigneron, Daniel B.; Ardenkjaer-Larsen, Jan Henrik Neoplasia, Vol. 21, Issue 1 https://doi.org/10.1016/j.neo.2018.09.006	journal	January 2019
From LASER physics to the para-hydrogen pumped RASER Appelt, S.; Kentner, A.; Lehmkuhl, S. Progress in Nuclear Magnetic Resonance Spectroscopy, Vol. 114-115 https://doi.org/10.1016/j.pnmrs.2019.05.003	journal	October 2019
Clinical-Scale Production of Nearly Pure (>98.5%) Parahydrogen and Quantification by Benchtop NMR Spectroscopy Nantogma, Shiraz; Joalland, Baptiste; Wilkens, Ken Analytical Chemistry, Vol. 93, Issue 7 https://doi.org/10.1021/acs.analchem.0c05129	journal	February 2021
Instrumentation for Hydrogenative Parahydrogen-Based Hyperpolarization Techniques Schmidt, Andreas B.; Bowers, C. Russell; Buckenmaier, Kai Analytical Chemistry, Vol. 94, Issue 1 https://doi.org/10.1021/acs.analchem.1c04863	journal	January 2022
Through-Space Multinuclear Magnetic Resonance Signal Enhancement Induced by Parahydrogen and Radiofrequency Amplification by Stimulated Emission of Radiation Salnikov, Oleg G.; Trofimov, Ivan A.; Pravdivtsev, Andrey N. Analytical Chemistry, Vol. 94, Issue 43 https://doi.org/10.1021/acs.analchem.2c02929	journal	October 2022
Spin Hyperpolarization in Modern Magnetic Resonance Eills, James; Budker, Dmitry; Cavagnero, Silvia Chemical Reviews, Vol. 123, Issue 4 https://doi.org/10.1021/acs.chemrev.2c00534	journal	January 2023
Interplay of Near-Zero-Field Dephasing, Rephasing, and Relaxation Dynamics and [1-¹³C]Pyruvate Polarization Transfer Efficiency in Pulsed SABRE-SHEATH Nantogma, Shiraz; Eriksson, Shannon L.; Adelabu, Isaiah The Journal of Physical Chemistry A, Vol. 126, Issue 48 https://doi.org/10.1021/acs.jpca.2c07150	journal	November 2022
Parahydrogen-Induced Polarization of 1-¹³C-Acetates and 1-¹³C-Pyruvates Using Sidearm Hydrogenation of Vinyl, Allyl, and Propargyl Esters Salnikov, Oleg G.; Chukanov, Nikita V.; Shchepin, Roman V. The Journal of Physical Chemistry C, Vol. 123, Issue 20 https://doi.org/10.1021/acs.jpcc.9b02041	journal	April 2019
A Magic Angle Spinning Activated ¹⁷ O DNP Raser Hope, Michael A.; Björgvinsdóttir, Snædís; Grey, Clare P. The Journal of Physical Chemistry Letters, Vol. 12, Issue 1 https://doi.org/10.1021/acs.jpclett.0c03457	journal	December 2020
Scanning Nuclear Spin Level Anticrossings by Constant-Adiabaticity Magnetic Field Sweeping of Parahydrogen-Induced ¹³C Polarization Joalland, Baptiste; Chekmenev, Eduard Y. The Journal of Physical Chemistry Letters, Vol. 13, Issue 8 https://doi.org/10.1021/acs.jpclett.2c00029	journal	February 2022
Synthesis of Unsaturated Precursors for Parahydrogen-Induced Polarization and Molecular Imaging of 1-¹³C-Acetates and 1-¹³C-Pyruvates via Side Arm Hydrogenation Chukanov, Nikita V.; Salnikov, Oleg G.; Shchepin, Roman V. ACS Omega, Vol. 3, Issue 6 https://doi.org/10.1021/acsomega.8b00983	journal	June 2018
Catalyst-Free Aqueous Hyperpolarized [1-¹³C]Pyruvate Obtained by Re-Dissolution Signal Amplification by Reversible Exchange Schmidt, Andreas B.; de Maissin, Henri; Adelabu, Isaiah ACS Sensors, Vol. 7, Issue 11 https://doi.org/10.1021/acssensors.2c01715	journal	November 2022
Para hydrogen induced polarization in hydrogenation reactions Eisenschmid, Thomas C.; Kirss, Rein U.; Deutsch, Paul P. Journal of the American Chemical Society, Vol. 109, Issue 26 https://doi.org/10.1021/ja00260a026	journal	December 1987
Temperature Cycling Enables Efficient ¹³C SABRE-SHEATH Hyperpolarization and Imaging of [1-¹³C]-Pyruvate TomHon, Patrick; Abdulmojeed, Mustapha; Adelabu, Isaiah Journal of the American Chemical Society, Vol. 144, Issue 1 https://doi.org/10.1021/jacs.1c09581	journal	December 2021
Parahydrogen-Polarized Fumarate for Preclinical in Vivo Metabolic Magnetic Resonance Imaging Gierse, Martin; Nagel, Luca; Keim, Michael Journal of the American Chemical Society, Vol. 145, Issue 10 https://doi.org/10.1021/jacs.2c13830	journal	March 2023
¹³C Radiofrequency Amplification by Stimulated Emission of Radiation Threshold Sensing of Chemical Reactions Schmidt, Andreas B.; Adelabu, Isaiah; Nelson, Christopher Journal of the American Chemical Society, Vol. 145, Issue 20 https://doi.org/10.1021/jacs.3c00776	journal	May 2023
Imaging Metabolism with Hyperpolarized ¹³C-Labeled Cell Substrates Brindle, Kevin M. Journal of the American Chemical Society, Vol. 137, Issue 20 https://doi.org/10.1021/jacs.5b03300	journal	May 2015
Liquid-state carbon-13 hyperpolarization generated in an MRI system for fast imaging Schmidt, A. B.; Berner, S.; Schimpf, W. Nature Communications, Vol. 8, Issue 1 https://doi.org/10.1038/ncomms14535	journal	March 2017
ParaHydrogen Induced Polarization of 13C carboxylate resonance in acetate and pyruvate Reineri, Francesca; Boi, Tommaso; Aime, Silvio Nature Communications, Vol. 6, Issue 1 https://doi.org/10.1038/ncomms6858	journal	January 2015
Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy Day, Sam E.; Kettunen, Mikko I.; Gallagher, Ferdia A. Nature Medicine, Vol. 13, Issue 11 https://doi.org/10.1038/nm1650	journal	October 2007
Para-hydrogen raser delivers sub-millihertz resolution in nuclear magnetic resonance Suefke, Martin; Lehmkuhl, Sören; Liebisch, Alexander Nature Physics, Vol. 13, Issue 6 https://doi.org/10.1038/nphys4076	journal	March 2017
The 13C hyperpolarized pyruvate generated by ParaHydrogen detects the response of the heart to altered metabolism in real time Cavallari, Eleonora; Carrera, Carla; Sorge, Matteo Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-26583-2	journal	May 2018
PHIP hyperpolarized [1-13C]pyruvate and [1-13C]acetate esters via PH-INEPT polarization transfer monitored by 13C NMR and MRI Svyatova, Alexandra; Kozinenko, Vitaly P.; Chukanov, Nikita V. Scientific Reports, Vol. 11, Issue 1 https://doi.org/10.1038/s41598-021-85136-2	journal	March 2021
Optimisation of pyruvate hyperpolarisation using SABRE by tuning the active magnetisation transfer catalyst Tickner, Ben. J.; Semenova, Olga; Iali, Wissam Catalysis Science & Technology, Vol. 10, Issue 5 https://doi.org/10.1039/C9CY02498K	journal	January 2020
Real-time metabolic imaging Golman, Klaes; in ‘t Zandt, René; Thaning, Mikkel Proceedings of the National Academy of Sciences, Vol. 103, Issue 30 https://doi.org/10.1073/pnas.0601319103	journal	July 2006
Hyperpolarized ¹³ C allows a direct measure of flux through a single enzyme-catalyzed step by NMR Merritt, Matthew E.; Harrison, Crystal; Storey, Charles Proceedings of the National Academy of Sciences, Vol. 104, Issue 50 https://doi.org/10.1073/pnas.0706235104	journal	December 2007
Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR Ardenkjaer-Larsen, J. H.; Fridlund, B.; Gram, A. Proceedings of the National Academy of Sciences, Vol. 100, Issue 18 https://doi.org/10.1073/pnas.1733835100	journal	August 2003
Fundamentals of Spin-Exchange Optical Pumping Walker, Thad G. Journal of Physics: Conference Series, Vol. 294 https://doi.org/10.1088/1742-6596/294/1/012001	journal	June 2011
Exploring synchrony and chaos of parahydrogen-pumped two-compartment radio-frequency amplification by stimulated emission of radiation Lohmann, Lars; Lehmkuhl, Sören; Fleischer, Simon Physical Review A, Vol. 108, Issue 2 https://doi.org/10.1103/PhysRevA.108.022806	journal	August 2023
Improved frequency stability of the dual-noble-gas maser Bear, D.; Chupp, T. E.; Cooper, K. Physical Review A, Vol. 57, Issue 6 https://doi.org/10.1103/PhysRevA.57.5006	journal	June 1998
Transformation of Symmetrization Order to Nuclear-Spin Magnetization by Chemical Reaction and Nuclear Magnetic Resonance Bowers, C. Russell; Weitekamp, Daniel P. Physical Review Letters, Vol. 57, Issue 21 https://doi.org/10.1103/PhysRevLett.57.2645	journal	November 1986
Parametric Amplification of Magnetic Resonance Images Syms, Richard R. A.; Floume, Timmy; Young, Ian R. IEEE Sensors Journal, Vol. 12, Issue 6 https://doi.org/10.1109/JSEN.2011.2176928	journal	June 2012
Signal Sensitivity Enhancement of High-Spatial-Resolution MR Imaging With a Concatenated Cylindrical Parametric RF-Resonator Timilsina, Roshan; Fan, Baolei; Qian, Chunqi IEEE Sensors Journal, Vol. 19, Issue 9 https://doi.org/10.1109/JSEN.2019.2894298	journal	May 2019
High Resolution $^{13}$C MRI With Hyperpolarized Urea: In Vivo $T_{2}$ Mapping and $^{15}$N Labeling Effects Reed, Galen D.; von Morze, Cornelius; Bok, Robert IEEE Transactions on Medical Imaging, Vol. 33, Issue 2 https://doi.org/10.1109/TMI.2013.2285120	journal	February 2014
RASER MRI: Magnetic resonance images formed spontaneously exploiting cooperative nonlinear interaction Lehmkuhl, Sören; Fleischer, Simon; Lohmann, Lars Science Advances, Vol. 8, Issue 28 https://doi.org/10.1126/sciadv.abp8483	journal	July 2022
Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized [1- ¹³ C]Pyruvate Nelson, Sarah J.; Kurhanewicz, John; Vigneron, Daniel B. Science Translational Medicine, Vol. 5, Issue 198 https://doi.org/10.1126/scitranslmed.3006070	journal	August 2013
Oxidative Phosphorylation as an Emerging Target in Cancer Therapy Ashton, Thomas M.; McKenna, W. Gillies; Kunz-Schughart, Leoni A. Clinical Cancer Research, Vol. 24, Issue 11 https://doi.org/10.1158/1078-0432.CCR-17-3070	journal	February 2018
Hyperpolarized ¹³ C Metabolic MRI of the Human Heart Cunningham, Charles H.; Lau, Justin Y. C.; Chen, Albert P. Circulation Research, Vol. 119, Issue 11 https://doi.org/10.1161/CIRCRESAHA.116.309769	journal	November 2016
Analysis of Cancer Metabolism by Imaging Hyperpolarized Nuclei: Prospects for Translation to Clinical Research Kurhanewicz, John; Vigneron, Daniel B.; Brindle, Kevin Neoplasia, Vol. 13, Issue 2 https://doi.org/10.1593/neo.101102	journal	February 2011
Recommendations on the Use of 18F-FDG PET in Oncology Fletcher, J. W.; Djulbegovic, B.; Soares, H. P. Journal of Nuclear Medicine, Vol. 49, Issue 3 https://doi.org/10.2967/jnumed.107.047787	journal	February 2008
Effectiveness and Safety of ¹⁸F-FDG PET in the Evaluation of Dementia: A Review of the Recent Literature Bohnen, Nicolaas I.; Djang, David S. W.; Herholz, Karl Journal of Nuclear Medicine, Vol. 53, Issue 1 https://doi.org/10.2967/jnumed.111.096578	journal	December 2011

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Carbon-13 Radiofrequency Amplification by Stimulated Emission of Radiation of the Hyperpolarized Ketone and Hemiketal Forms of Allyl [1-13C]Pyruvate

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Carbon-13 Radiofrequency Amplification by Stimulated Emission of Radiation of the Hyperpolarized Ketone and Hemiketal Forms of Allyl [1-¹³C]Pyruvate