{sup 1}H NMR-based spectroscopy detects metabolic alterations in serum of patients with early-stage ulcerative colitis

Journal Article · Fri Apr 19 04:00:00 EDT 2013 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/J.BBRC.2013.03.012· OSTI ID:22239551

Zhang, Ying; Lin, Lianjie ^[1]; Xu, Yanbin ^[2]; Lin, Yan; Jin, Yu ^[1]; Zheng, Changqing ^[1]

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1. Second Department of Gastroenterology, Shengjing Hospital, China Medical University, Shenyang 110004 (China)
2. Wanlei Life Sciences (Shenyang) Co., Ltd., Shenyang 110179 (China)

Highlights: •Twenty ulcerative colitis patients and nineteen healthy controls were enrolled. •Increased 3-hydroxybutyrate, glucose, phenylalanine, and decreased lipid were found. •We report early stage diagnosis of ulcerative colitis using NMR-based metabolomics. -- Abstract: Ulcerative colitis (UC) has seriously impaired the health of citizens. Accurate diagnosis of UC at an early stage is crucial to improve the efficiency of treatment and prognosis. In this study, proton nuclear magnetic resonance ({sup 1}H NMR)-based metabolomic analysis was performed on serum samples collected from active UC patients (n = 20) and healthy controls (n = 19), respectively. The obtained spectral profiles were subjected to multivariate data analysis. Our results showed that consistent metabolic alterations were present between the two groups. Compared to healthy controls, UC patients displayed increased 3-hydroxybutyrate, β-glucose, α-glucose, and phenylalanine, but decreased lipid in serum. These findings highlight the possibilities of NMR-based metabolomics as a non-invasive diagnostic tool for UC.

• OSTI ID: 22239551
• Journal Information: Biochemical and Biophysical Research Communications, Journal Name: Biochemical and Biophysical Research Communications Journal Issue: 4 Vol. 433; ISSN 0006-291X; ISSN BBRCA9
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
DATA ANALYSIS
DIAGNOSIS
GLUCOSE
LIPIDS
MULTIVARIATE ANALYSIS
NUCLEAR MAGNETIC RESONANCE
PATIENTS
PHENYLALANINE
PROTONS
SPECTROSCOPY
URANIUM CARBIDES