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Title: CT findings in ulcerative, granulomatous, and indeterminate colitis

Abstract

Eight patients with ulcerative colitis, three with colitis indeterminate, and 15 patients with Crohn disease were studied by computed tomography (CT) to establish CT criteria for each disorder in hopes of providing a new diagnostic perspective useful in the radiographic evaluation of inflammatory colitis. The CT findings in ulcerative colitis included thickening of the colon wall, which was characterized by inhomogeneous attenuation and a target appearance of the rectum, and proliferation of perirectal fat. Bowel wall thickening with homogeneous attenuation, fistula and abscess formation, and mesenteric abnormalities were observed in patients with Crohn colitis. Patients with colitis indeterminate showed colonic changes on CT observed in both disorders. Initial experience suggests that CT can differentiate patients with well established ulcerative and Crohn colitis.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Northwestern Univ. Medical School, Chicago, IL
OSTI Identifier:
6867174
Resource Type:
Journal Article
Resource Relation:
Journal Name: AJR, Am. J. Roentgenol.; (United States); Journal Volume: 143:2
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; DIGESTIVE SYSTEM DISEASES; DIAGNOSIS; LARGE INTESTINE; COMPUTERIZED TOMOGRAPHY; RECTUM; ABSCESSES; FISTULAE; PATIENTS; ULCERS; BODY; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DISEASES; GASTROINTESTINAL TRACT; INTESTINES; ORGANS; PATHOLOGICAL CHANGES; TOMOGRAPHY 550602* -- Medicine-- External Radiation in Diagnostics-- (1980-); 550900 -- Pathology

Citation Formats

Gore, R.M., Marn, C.S., Kirby, D.F., Vogelzang, R.L., and Neiman, H.L. CT findings in ulcerative, granulomatous, and indeterminate colitis. United States: N. p., 1984. Web. doi:10.2214/ajr.143.2.279.
Gore, R.M., Marn, C.S., Kirby, D.F., Vogelzang, R.L., & Neiman, H.L. CT findings in ulcerative, granulomatous, and indeterminate colitis. United States. doi:10.2214/ajr.143.2.279.
Gore, R.M., Marn, C.S., Kirby, D.F., Vogelzang, R.L., and Neiman, H.L. 1984. "CT findings in ulcerative, granulomatous, and indeterminate colitis". United States. doi:10.2214/ajr.143.2.279.
@article{osti_6867174,
title = {CT findings in ulcerative, granulomatous, and indeterminate colitis},
author = {Gore, R.M. and Marn, C.S. and Kirby, D.F. and Vogelzang, R.L. and Neiman, H.L.},
abstractNote = {Eight patients with ulcerative colitis, three with colitis indeterminate, and 15 patients with Crohn disease were studied by computed tomography (CT) to establish CT criteria for each disorder in hopes of providing a new diagnostic perspective useful in the radiographic evaluation of inflammatory colitis. The CT findings in ulcerative colitis included thickening of the colon wall, which was characterized by inhomogeneous attenuation and a target appearance of the rectum, and proliferation of perirectal fat. Bowel wall thickening with homogeneous attenuation, fistula and abscess formation, and mesenteric abnormalities were observed in patients with Crohn colitis. Patients with colitis indeterminate showed colonic changes on CT observed in both disorders. Initial experience suggests that CT can differentiate patients with well established ulcerative and Crohn colitis.},
doi = {10.2214/ajr.143.2.279},
journal = {AJR, Am. J. Roentgenol.; (United States)},
number = ,
volume = 143:2,
place = {United States},
year = 1984,
month = 8
}
  • Bowel-wall tissue filtrates from patients with inflammatory bowel disease produce cytopathic effects in tissue culture. The cytopathic effects inducers have been reported to have the characteristics of a small RNA virus. Clostridium difficile toxin also produces cytopathic effects and has been found in the stools of patients with Crohn's disease and ulcerative colitis. The present study concerns the further characterization of the cytopathic inducers in tissues of inflammatory bowel disease patients. It was found that they are nonsedimentable at 148,000 g for 2 h and resistant to inactivation by UV light. They are proteins that are distinct from C. difficilemore » toxin and are unique cytotoxins which are associated with the early cytopathic effects observed in Riff-free chick embryo and rabbit ileum cell cultures. These results suggest that the early cytopathic effects previously described are not produced by a virus. They do not explain the delayed cytopathic effects seen in rabbit ileum or WI-38 cells.« less
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