Localized accumulation of lead within and among bones from lead-dosed goats

Journal Article · Fri Jan 15 04:00:00 EST 2010 · Environmental Research

DOI:https://doi.org/10.1016/J.ENVRES.2009.09.005· OSTI ID:22149208

Cretacci, Yan ^[1]

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1. Laboratory of Inorganic and Nuclear Chemistry, Wadsworth Center, New York State Department of Health, P.O. Box 509, Albany, NY 12201-0509 (United States)

The principal aim of this study was to gain a better understanding of where lead (Pb) accumulates and how it is distributed, within the bones of dosed goats. Adult goats were periodically dosed with Pb over a number of years for the primary purpose of producing blood pools containing endogenously bound Pb, for the New York State Blood Lead Proficiency Testing Program. Bone samples (e.g., primarily tibia, femur, humerus, and radius) were collected post-mortem from 11 animals and were analyzed for Pb content by acid digestion and electrothermal atomic absorption spectrometry (ETAAS or GFAAS). Average tibia Pb levels were found to correlate strongly with the cumulative Pb dose (r{sup 2}=0.81). However, the concentration of Pb in different bones and even within a small area of the same bone varied tremendously. Blood-rich trabecular (spongy) bone, such as the patella and calcaneus, were much more enriched in Pb than was cortical (compact) bone. In some dosed animals, the Pb concentration in the tibia was markedly higher at the proximal and distal ends of the bone compared to the mid-shaft. The implications of these findings with regard to the noninvasive measurement of lead in bone by XRF methods are discussed.

• OSTI ID: 22149208
• Journal Information: Environmental Research, Journal Name: Environmental Research Journal Issue: 1 Vol. 110; ISSN ENVRAL; ISSN 0013-9351
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ABSORPTION SPECTROSCOPY
BLOOD
CONCENTRATION RATIO
DOSES
ECOLOGICAL CONCENTRATION
FEMUR
GOATS
LEAD
TIBIA
X-RAY FLUORESCENCE ANALYSIS