High-dose radiotherapy in inoperable nonsmall cell lung cancer: Comparison of volumetric modulated arc therapy, dynamic IMRT and 3D conformal radiotherapy

Journal Article · Sun Jan 01 04:00:00 EST 2012 · Medical Dosimetry

DOI:https://doi.org/10.1016/J.MEDDOS.2011.12.002· OSTI ID:22131247

Veelen, Lieneke R. van ^[1]

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1. Zeeuws Radiotherapeutisch Instituut, Vlissingen (Netherlands)

Conformal 3D radiotherapy (3D-CRT) combined with chemotherapy for inoperable non-small cell lung cancer (NSCLC) to the preferable high dose is often not achievable because of dose-limiting organs. This reduces the probability of regional tumor control. Therefore, the surplus value of using intensity-modulated radiation therapy (IMRT) techniques, specifically volumetric modulated arc therapy (RapidArc [RA]) and dynamic IMRT (d-IMRT) has been investigated. RA and d-IMRT plans were compared with 3D-CRT treatment plans for 20 patients eligible for concurrent high-dose chemoradiotherapy, in whom a dose of 60 Gy was not achievable. Comparison of dose delivery in the target volume and organs at risk was carried out by evaluating 3D dose distributions and dose-volume histograms. Quality of the dose distribution was assessed using the inhomogeneity and conformity index. For most patients, a higher dose to the target volume can be delivered using RA or d-IMRT; in 15% of the patients a dose {>=}60 Gy was possible. Both IMRT techniques result in a better conformity of the dose (p < 0.001). There are no significant differences in homogeneity of dose in the target volume. IMRT techniques for NSCLC patients allow higher dose to the target volume, thus improving regional tumor control.

• OSTI ID: 22131247
• Journal Information: Medical Dosimetry, Journal Name: Medical Dosimetry Journal Issue: 4 Vol. 37; ISSN 0958-3947
• Country of Publication: United States
• Language: English

Related Subjects

61 RADIATION PROTECTION AND DOSIMETRY
CHEMOTHERAPY
COMBINED THERAPY
COMPARATIVE EVALUATIONS
CONTROL
DOSIMETRY
HEALTH HAZARDS
LUNGS
NEOPLASMS
PATIENTS
PROBABILITY
RADIATION DOSE DISTRIBUTIONS
RADIATION DOSES
RADIOTHERAPY