Low-Dose Radiation Treatment in Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma: A Plausible Approach? A Single-Institution Experience in 10 Patients

Journal Article · Sun Jul 01 04:00:00 EDT 2012 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/J.IJROBP.2012.01.005· OSTI ID:22058919

Girinsky, Theodore ^[1]; Paumier, Amaury ^[1]; Ferme, Christophe; Hanna, Colette; Ribrag, Vincent ^[2]; Leroy-Ladurie, Francois ^[3]; Ghalibafian, Mithra ^[1]

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1. Department of Radiation Oncology, Institut Gustave Roussy, Villejuif (France)
2. Department of Hematology, Institut Gustave Roussy, Villejuif (France)
3. Department of Thoracic Surgery, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson (France)

Purpose: To propose an alternative approach for treatment of pulmonary marginal zone lymphoma, using a very small radiation dose (2 Multiplication-Sign 2 Gy) delivered exclusively to tumor sites. Methods and Materials: Patients had localized pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma according to the World Health Organization classification. The 6-MV radiation treatments were delivered using tumor-limited fields, except in cases of diffuse bilateral involvement. Two daily fractions of 2 Gy were delivered to tumor-limited fields using a 6-MV linear accelerator. Results: Ten patients with pulmonary MALT lymphoma entered the study. All but 1 had localized tumor masses. The median follow-up was 56 months (range, 2-103 months). Complete remission or an unconfirmed complete remission was obtained in 60% of patients within the first 2 months, and two additional partial responses were converted into a long-term unconfirmed complete remission. All patients are well and alive, no local progression was observed, and the 5-year progression-free survival rate was 87.5% (95% confidence interval 49%-97%). Conclusions: Our results suggest that extremely low radiation doses delivered exclusively to tumor sites might be a treatment option in pulmonary MALT lymphoma.

• OSTI ID: 22058919
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 3 Vol. 83; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CLASSIFICATION
LINEAR ACCELERATORS
LYMPHOMAS
MUCOUS MEMBRANES
PATIENTS
RADIATION DOSES
RADIOTHERAPY
STANDARD OF LIVING