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Title: Treatment Effects and Sequelae of Radiation Therapy for Orbital Mucosa-Associated Lymphoid Tissue Lymphoma

Abstract

Purpose: Among extranodal lymphomas, orbital mucosa-associated lymphoid tissue (MALT) lymphoma is a relatively rare presentation. We performed a review to ascertain treatment efficacy and toxicity of radiation therapy for orbital MALT lymphoma. We also evaluated changes in visual acuity after irradiation. Methods and Materials: Thirty patients with orbital MALT lymphoma underwent radiation therapy with curative intent. Clinical stages at diagnosis were stage I{sub E}A in 29 patients and stage II{sub E}A in 1 patient. Total doses of 28.8 to 45.8 Gy (median, 30 Gy) in 15 to 26 fractions (median, 16 fractions) were delivered to the tumors. Results: All irradiated tumors were controlled during the follow-up period of 2 to 157 months (median, 35 months) after treatment. Two patients had relapses that arose in the cervical lymph node and the ipsilateral palpebral conjunctiva outside the radiation field at 15 and 67 months after treatment, respectively. The 5-year local progression-free and relapse-free rates were 100% and 96%, respectively. All 30 patients are presently alive; the overall and relapse-free survival rates at 5 years were 100% and 96%, respectively. Although 5 patients developed cataracts of grade 2 at 8 to 45 months after irradiation, they underwent intraocular lens implantation, and their eyesightmore » recovered. Additionally, there was no marked deterioration in the visual acuity of patients due to irradiation, with the exception of cataracts. No therapy-related toxicity of grade 3 or greater was observed. Conclusions: Radiation therapy was effective and safe for patients with orbital MALT lymphoma. Although some patients developed cataracts after irradiation, visual acuity was well preserved.« less

Authors:
 [1]; ;  [1];  [2];  [3]; ; ;  [1];  [4];  [1]
  1. Department of Radiology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa (Japan)
  2. Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa (Japan)
  3. Department of Ophthalmology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa (Japan)
  4. Department of Radiation Oncology, Yokohama City University Medical Center, Yokohama, Kanagawa (Japan)
Publication Date:
OSTI Identifier:
22054495
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 81; Journal Issue: 5; Other Information: Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CATARACTS; CONJUNCTIVA; DIAGNOSIS; IRRADIATION; LENSES; LYMPH NODES; LYMPHOMAS; PATIENTS; RADIATION DOSES; RADIOTHERAPY; TOXICITY

Citation Formats

Hata, Masaharu, E-mail: mhata@syd.odn.ne.jp, Omura, Motoko, Koike, Izumi, Tomita, Naoto, Iijima, Yasuhito, Tayama, Yoshibumi, Odagiri, Kazumasa, Minagawa, Yumiko, Ogino, Ichiro, and Inoue, Tomio. Treatment Effects and Sequelae of Radiation Therapy for Orbital Mucosa-Associated Lymphoid Tissue Lymphoma. United States: N. p., 2011. Web. doi:10.1016/J.IJROBP.2010.07.1992.
Hata, Masaharu, E-mail: mhata@syd.odn.ne.jp, Omura, Motoko, Koike, Izumi, Tomita, Naoto, Iijima, Yasuhito, Tayama, Yoshibumi, Odagiri, Kazumasa, Minagawa, Yumiko, Ogino, Ichiro, & Inoue, Tomio. Treatment Effects and Sequelae of Radiation Therapy for Orbital Mucosa-Associated Lymphoid Tissue Lymphoma. United States. doi:10.1016/J.IJROBP.2010.07.1992.
Hata, Masaharu, E-mail: mhata@syd.odn.ne.jp, Omura, Motoko, Koike, Izumi, Tomita, Naoto, Iijima, Yasuhito, Tayama, Yoshibumi, Odagiri, Kazumasa, Minagawa, Yumiko, Ogino, Ichiro, and Inoue, Tomio. Thu . "Treatment Effects and Sequelae of Radiation Therapy for Orbital Mucosa-Associated Lymphoid Tissue Lymphoma". United States. doi:10.1016/J.IJROBP.2010.07.1992.
@article{osti_22054495,
title = {Treatment Effects and Sequelae of Radiation Therapy for Orbital Mucosa-Associated Lymphoid Tissue Lymphoma},
author = {Hata, Masaharu, E-mail: mhata@syd.odn.ne.jp and Omura, Motoko and Koike, Izumi and Tomita, Naoto and Iijima, Yasuhito and Tayama, Yoshibumi and Odagiri, Kazumasa and Minagawa, Yumiko and Ogino, Ichiro and Inoue, Tomio},
abstractNote = {Purpose: Among extranodal lymphomas, orbital mucosa-associated lymphoid tissue (MALT) lymphoma is a relatively rare presentation. We performed a review to ascertain treatment efficacy and toxicity of radiation therapy for orbital MALT lymphoma. We also evaluated changes in visual acuity after irradiation. Methods and Materials: Thirty patients with orbital MALT lymphoma underwent radiation therapy with curative intent. Clinical stages at diagnosis were stage I{sub E}A in 29 patients and stage II{sub E}A in 1 patient. Total doses of 28.8 to 45.8 Gy (median, 30 Gy) in 15 to 26 fractions (median, 16 fractions) were delivered to the tumors. Results: All irradiated tumors were controlled during the follow-up period of 2 to 157 months (median, 35 months) after treatment. Two patients had relapses that arose in the cervical lymph node and the ipsilateral palpebral conjunctiva outside the radiation field at 15 and 67 months after treatment, respectively. The 5-year local progression-free and relapse-free rates were 100% and 96%, respectively. All 30 patients are presently alive; the overall and relapse-free survival rates at 5 years were 100% and 96%, respectively. Although 5 patients developed cataracts of grade 2 at 8 to 45 months after irradiation, they underwent intraocular lens implantation, and their eyesight recovered. Additionally, there was no marked deterioration in the visual acuity of patients due to irradiation, with the exception of cataracts. No therapy-related toxicity of grade 3 or greater was observed. Conclusions: Radiation therapy was effective and safe for patients with orbital MALT lymphoma. Although some patients developed cataracts after irradiation, visual acuity was well preserved.},
doi = {10.1016/J.IJROBP.2010.07.1992},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 5,
volume = 81,
place = {United States},
year = {Thu Dec 01 00:00:00 EST 2011},
month = {Thu Dec 01 00:00:00 EST 2011}
}