The design and application of an in-laboratory diffraction-enhanced x-ray imaging instrument
- Nesch, LLC 9800 Connecticut Drive, Crown Point, Indiana 46307 (United States)
- Department of Biochemistry, Rush Medical College, 1735 W. Harrison St., Chicago, Illinois 60612 (United States)
- Department of Anatomy and Cell Biology, College of Medicine, B331 Life Sciences Building, 107 Wiggins Road, Saskatoon, Saskatchewan S7N5E5 (Canada)
We describe the design and application of a new in-laboratory diffraction-enhanced x-ray imaging (DEXI) instrument that uses a nonsynchrotron, conventional x-ray source to image the internal structure of an object. In the work presented here, a human cadaveric thumb is used as a test-sample to demonstrate the imaging capability of our instrument. A 22 keV monochromatic x-ray beam is prepared using a mismatched, two-crystal monochromator; a silicon analyzer crystal is placed in a parallel crystal geometry with the monochromator allowing both diffraction-enhanced imaging and multiple-imaging radiography to be performed. The DEXI instrument was found to have an experimentally determined spatial resolution of 160{+-}7 {mu}m in the horizontal direction and 153{+-}7 {mu}m in the vertical direction. As applied to biomedical imaging, the DEXI instrument can detect soft tissues, such as tendons and other connective tissues, that are normally difficult or impossible to image via conventional x-ray techniques.
- OSTI ID:
- 22051039
- Journal Information:
- Review of Scientific Instruments, Vol. 80, Issue 9; Other Information: (c) 2009 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); ISSN 0034-6748
- Country of Publication:
- United States
- Language:
- English
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