Mesoporous Organosilica Nanoparticles with Internal Metal–Chelating Groups: Transition Metal Uptake and Gd3+ Relaxivity

Walton, Nathan I.; Naha, Pratap C.; Cormode, David P.; Zharov, Ilya

doi:10.1002/slct.202301454

Mesoporous Organosilica Nanoparticles with Internal Metal–Chelating Groups: Transition Metal Uptake and Gd³⁺ Relaxivity

Journal Article · Thu Sep 07 00:00:00 EDT 2023 · Chemistry Select

DOI:https://doi.org/10.1002/slct.202301454· OSTI ID:2204478

Walton, Nathan I. ^[1]; Naha, Pratap C. ^[2]; Cormode, David P. ^[2]; ^[3]

University of Utah, Salt Lake City, UT (United States); Univ. of Utah
University of Pennsylvania, Philadelphia, PA (United States)
University of Utah, Salt Lake City, UT (United States)

We prepared novel mesoporous organosilica nanoparticles with internal metal-chelating diethylenetriametetraacetic acid groups (DTTA-MSNPs) by co-condensation and decorated them with fluorescent moieties. Here, we studied the binding of transition metal ions such as copper(II), cobalt (II) and gadolinium (III) by DTTA-MSNPs, and found high uptake of these metals. In particular, DTTA-MSNPs uptake ~1.1×10⁵ Gd³⁺ per particle and possess a high r₁ relaxivity of 15.27 mM^–1 s^–1. Thus, DTTA-MSNPs may find applications in metal sequestration and in MR imaging and neutron capture therapy.

View Accepted Manuscript (DOE)

Research Organization:: University of Utah, Salt Lake City, UT (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: SC0019285

OSTI ID:: 2204478

Journal Information:: Chemistry Select, Journal Name: Chemistry Select Journal Issue: 34 Vol. 8; ISSN 2365-6549

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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Mesoporous Organosilica Nanoparticles with Internal Metal–Chelating Groups: Transition Metal Uptake and Gd³⁺ Relaxivity