Periodic mesoporous organosilicas with co-existence of diurea and sulfanilamide as an effective drug delivery carrier

Journal Article · Sun May 15 04:00:00 UTC 2011 · Journal of Solid State Chemistry

DOI:https://doi.org/10.1016/j.jssc.2011.03.003· OSTI ID:21494305

Parambadath, Surendran; Rana, Vijay Kumar; Moorthy, Santha; Chu, Sang-Wook; Park, Shin-Kyu; Lee, Daewoo; Sung, Giju ^[1]; Ha, Chang-Sik ^[1]

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1. Department of Polymer Science and Engineering, Pusan National University, Geumjeong-gu, Busan 609-735 (Korea, Republic of)

In this article we report the synthesis of new periodic mesoporous organosilicas (PMOs) with the co-existence of diurea and sulfanilamide-bridged organosilica that are potentially useful for controlled drug release system. The materials possess hexagonal pores with a high degree of uniformity and show long-range order as confirmed by the measurements of small-angle X-ray scattering (SAXS), N{sub 2} adsorption isotherms, and transmission electron microscopy(TEM). FT-IR and solid state {sup 29}Si MAS and {sup 13}C CP MAS NMR spectroscopic analyses proved that the bridging groups in the framework are not cleaved and covalently attached in the walls of the PMOs. It was found that the organic functionality could be introduced in a maximum of 10 mol% with respect to the total silicon content and be thermally stable up to 230 {sup o}C. The synthesized materials were shown to be particularly suitable for adsorption and desorption of hydrophilic/hydrophobic drugs from a phosphate buffer solution at pH 7.4. -- Graphical Abstract: We report the synthesis of new periodic mesoporous organosilicas (PMOs) with the co-existence of diurea and sulfanilamide-bridged organosilica that are potentially useful for controlled drug release system. Display Omitted Highlights: {yields} Synthesis of new periodic mesoporous organosilicas (PMOs) with the co-existence of diurea and sulfanilamide-bridged organosilica that are potentially useful for controlled drug release system. {yields} The organic functionality could be introduced in a maximum of 10 mol% with respect to the total silicon content and be thermally stable up to 230 {sup o}C. {yields} The synthesized materials were shown to be particularly suitable for adsorption and desorption of hydrophilic/hydrophobic drugs from a phosphate buffer solution at pH 7.4.

• OSTI ID: 21494305
• Journal Information: Journal of Solid State Chemistry, Journal Name: Journal of Solid State Chemistry Journal Issue: 5 Vol. 184; ISSN 0022-4596; ISSN JSSCBI
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
ADSORPTION
ADSORPTION ISOTHERMS
COHERENT SCATTERING
DELIVERY
DESORPTION
DIFFRACTION
DRUGS
ELECTRON MICROSCOPY
ELEMENTS
INFRARED SPECTRA
ISOTHERMS
MAGNETIC RESONANCE
MICROSCOPY
NANOSTRUCTURES
NUCLEAR MAGNETIC RESONANCE
OXYGEN COMPOUNDS
PHOSPHATES
PHOSPHORUS COMPOUNDS
RESONANCE
SCATTERING
SEMIMETALS
SILICON
SMALL ANGLE SCATTERING
SORPTION
SPECTRA
SYNTHESIS
TEMPERATURE RANGE
TEMPERATURE RANGE 0400-1000 K
TRANSMISSION ELECTRON MICROSCOPY
X-RAY DIFFRACTION