Evaluation of Radiation Dose Effects on Rat Bones Using Synchrotron Radiation Computed Microtomography
- Nuclear Instrumentation Laboratory / COPPE / UFRJ, P.O. Box 68509, 21945-970, Rio de Janeiro (Brazil)
- Physics Institute / State University of Rio de Janeiro, 20550-900, Rio de Janeiro (Brazil)
- Laboratory of Radiological Sciences / State University of Rio de Janeiro, Rio de Janeiro (Brazil)
- Sincrotrone Trieste SCpA, Strada Statale S.S. 14 km 163.5, 34012 Basovizza, Trieste (Italy)
In this work, we investigated the consequences of irradiation in the femora and ribs of rats submitted to radiation doses of 5 Gy. Three different sites in femur specimens (head, distal metaphysis and distal epiphysis) and one in ribs (ventral) were imaged using synchrotron radiation microcomputed tomography to assess trabecular bone microarchitecture. Histomorphometric quantification was calculated directly from the 3D microtomographic images using synchrotron radiation. The 3D microtomographic images were obtained at the SYRMEP (SYnchrotron Radiation for MEdical Physics) beamline at the Elettra Synchrotron Laboratory in Trieste, Italy. A better understanding of the biological interactions that occur after exposure to photon radiation is needed in order to optimize therapeutic regimens and facilitate development and strategies that decrease radiation-induced side effects in humans. Results showed significant differences between irradiated and non-irradiated specimens, mostly in head and distal metaphysis bone sites.
- OSTI ID:
- 22003931
- Journal Information:
- AIP Conference Proceedings, Vol. 1412, Issue 1; Conference: 11. international conference on applications of nuclear techniques, Crete (Greece), 12-18 Jun 2011; Other Information: (c) 2011 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-243X
- Country of Publication:
- United States
- Language:
- English
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