The NACP/synuclein gene: Chromosomal assignment and screening for alterations in Alzheimer disease
- CHR, Rouen (France)
- Unite de Genetique, Rouen (France); and others
The major component of the vascular and plaque amyloid deposits in Alzheimer disease is the amyloid {beta} peptide (A{beta}). A second intrinsic component of amyloid, the NAC (non-A{beta} component of amyloid) peptide, has recently been identified, and its precursor protein was named NACP. A computer homology search allowed us to establish that the human NACP gene was homologous to the rat synuclein gene. We mapped the NACP/synuclein gene to chromosome 4 and cloned three alternatively spliced transcripts in lymphocytes derived from a normal subject. We analyzed by RT-PCR and direct sequencing the entire coding region of the NACP/synuclein gene in a group of patients with familial early onset Alzheimer disease. No mutation was found in 26 unrelated patients. Further studies are required to investigate the implication of the NACP/synuclein gene in Alzheimer disease. 21 refs., 3 tabs.
- OSTI ID:
- 219887
- Journal Information:
- Genomics, Vol. 26, Issue 2; Other Information: PBD: 20 Mar 1995
- Country of Publication:
- United States
- Language:
- English
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