Chromosomal localization of the parathyroid hormone/parathyroid hormone-related protein receptor gene to human chromosome 3p21.1-p24.2
- Univ. of Utah Health Sciences Center, Salt Lake City, UT (United States)
- Massachusetts General Hospital, Boston, MA (United States); and others
The human PTH/PTH-related peptide (PTH/PTHrP) receptor could be involved in hereditary disorders of PTH or PTHrP action. Knowledge of the gene`s chromosomal location would allow studies linking it to specific disease traits. Therefore, we mapped the human PTH/PTHrP receptor gene by polymerase chain reaction of human/rodent somatic cell hybrid panels using oligonucleotide primers designed to amplify a portion of the gene from genomic DNA. The PTH/PTHrP gene was unambiguously assigned to the short arm of human chromosome 3, in the region designated 3p21.1-p24.2. Analysis of a second chromosome 3-specific mapping panel suggests that the gene is located near the 3p21.2-p21.3 boundary. The availability of highly polymorphic markers located in this region will permit exploration of the PTH/PTHrP receptor locus in genetic linkage searches for the causes of bone, calcium, and other potential disorders. 14 refs., 2 figs.
- OSTI ID:
- 219876
- Journal Information:
- Journal of Clinical Endocrinology and Metabolism, Vol. 79, Issue 4; Other Information: PBD: Oct 1994
- Country of Publication:
- United States
- Language:
- English
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