Organochlorine-induced immunosuppression in fish-eating birds of the Great Lakes
Conference
·
OSTI ID:218476
- Calvin College, Grand Rapids, MI (United States). Dept. of Biology
- Virginia Polytechnic Inst. and State Univ., Blacksburg, VA (United States)
- Canadian Wildlife Service, Hull, Quebec (Canada)
This investigation studied the effects of environmental contaminants on immune function in fish-eating birds of the Great Lakes and evaluated the use of immunological tests as biomarkers for contaminant exposure in wild birds. During 1991--1994, specific immune functions and general hematological parameters were measured in herring gull (Larus argentatus) and Caspian tern (Stema caspia) chicks. Study sites were chosen across a wide range of organochlorine contamination caused primarily by PCBs. In herring gull adults, the heterophil to lymphocyte ratio decreased as liver EROD, an index of contaminant exposure, increased, In herring gull chicks, thymus mass decreased as EROD increased. At highly contaminated sites, gull and tern chicks showed a marked reduction in T cell-mediated immunity as measured by the phytohemagglutinin skin test. The thymic atrophy and T cell suppression were consistent with documented effects of PCBs in laboratory animals during development and growth. In both species, chicks exhibited biologically significant differences in antibody production among sites, but any relationships to contaminants or other factors remain unclear. In laboratory animals, PCBs exhibit variable effects on antibody production. Structural and functional parameters related to the immune system are useful biomarkers for assessing the effects of contaminants on wild birds.
- OSTI ID:
- 218476
- Report Number(s):
- CONF-9511137--; ISBN 1-880611-03-1
- Country of Publication:
- United States
- Language:
- English
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