A Signal-Inducing Bone Cement for Magnetic Resonance Imaging-Guided Spinal Surgery Based on Hydroxyapatite and Polymethylmethacrylate

Journal Article · Fri Jun 15 04:00:00 EDT 2012 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-011-0192-0· OSTI ID:21608533

Wichlas, Florian; Seebauer, Christian J; Schilling, Rene ^[1]; Rump, Jens ^[2]; Chopra, Sascha S ^[1]; Walter, Thula; Teichgraeber, Ulf K. M. ^[2]; Bail, Hermann J ^[1]

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1. University Charite, Center for Musculoskeletal Surgery (Germany)
2. University Charite, Department of Radiology (Germany)

The aim of this study was to develop a signal-inducing bone cement for magnetic resonance imaging (MRI)-guided cementoplasty of the spine. This MRI cement would allow precise and controlled injection of cement into pathologic lesions of the bone. We mixed conventional polymethylmethacrylate bone cement (PMMA; 5 ml methylmethacrylate and 12 g polymethylmethacrylate) with hydroxyapatite (HA) bone substitute (2-4 ml) and a gadolinium-based contrast agent (CA; 0-60 {mu}l). The contrast-to-noise ratio (CNR) of different CA doses was measured in an open 1.0-Tesla scanner for fast T1W Turbo-Spin-Echo (TSE) and T1W TSE pulse sequences to determine the highest signal. We simulated MRI-guided cementoplasty in cadaveric spines. Compressive strength of the cements was tested. The highest CNR was (1) 87.3 (SD 2.9) in fast T1W TSE for cements with 4 {mu}l CA/ml HA (4 ml) and (2) 60.8 (SD 2.4) in T1W TSE for cements with 1 {mu}l CA/ml HA (4 ml). MRI-guided cementoplasty in cadaveric spine was feasible. Compressive strength decreased with increasing amounts of HA from 46.7 MPa (2 ml HA) to 28.0 MPa (4 ml HA). An MRI-compatible cement based on PMMA, HA, and CA is feasible and clearly visible on MRI images. MRI-guided spinal cementoplasty using this cement would permit direct visualization of the cement, the pathologic process, and the anatomical surroundings.

• OSTI ID: 21608533
• Journal Information: Cardiovascular and Interventional Radiology, Journal Name: Cardiovascular and Interventional Radiology Journal Issue: 3 Vol. 35; ISSN 0174-1551; ISSN CAIRDG
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
APATITES
BODY
BUILDING MATERIALS
CEMENTS
DIAGNOSTIC TECHNIQUES
DOSES
ESTERS
IMAGES
INJECTION
INTAKE
MATERIALS
MEDICINE
MINERALS
NMR IMAGING
ORGANIC COMPOUNDS
ORGANIC POLYMERS
ORGANS
PHOSPHATE MINERALS
PMMA
POLYACRYLATES
POLYMERS
POLYVINYLS
PULSES
SIGNALS
SIMULATION
SKELETON
SPIN ECHO
SURGERY
VERTEBRAE