A Pilot Study of Uterine Artery Embolization with Tris-Acryl Gelatin Microspheres in Guinea Pigs

Journal Article · Fri Jun 15 00:00:00 EDT 2012 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-011-0215-X· OSTI ID:21608527

Wenquan, Zhuang; Guosheng, Tan; Jianyong, Yang ^[1]

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1. The First Affiliated Hospital of Sun Yat-sen University, Department of Radiology (China)

Objective: This study was designed to establish guinea pigs as an animal model for uterine artery embolization (UAE) with tris-acryl gelatin microspheres (TAGM). Methods: Twenty-five female adult guinea pigs were randomly divided into two groups, including a uterine artery casting mould group (n = 10) and a UAE group (n = 15). Pelvic angiography and vascular casting mould were performed in the first group. The anatomical characters of the pelvic cavity in guinea pigs were described. In the second group, the technical feasibility of performing UAE with TAGM in guinea pigs was investigated. The histopathological slides of the uterus of guinea pigs after UAE were examined to inspect the outcomes of UAE. Results: The uterine artery springs from the internal iliac artery, ascends tortuously along the cervix, and gives off vertically 8-10 branches to the cervix uteri and uterine horns. The diameters of the trunk of the uterine artery and its first branch were 0.32 {+-} 0.027 mm and 0.14 {+-} 0.01 mm, respectively. For UAE animals, the dosages of 40-120 and 100-300 {mu}m TAGM were 0.033 {+-} 0.003 ml and 0.015 {+-} 0.002 ml, respectively. On histopathological slides, embosphere particles were found in the first branches of the uterine artery, the subserous arteries, and the intramural arteries. Inflammatory reactions in the uterus were common in guinea pigs after UAE. Local or dispersed areas of necrosis in uterus also were observed in a few guinea pigs. Conclusions: Guinea pigs are an appropriate and feasible model for UAE with TAGM.

• OSTI ID: 21608527
• Journal Information: Cardiovascular and Interventional Radiology, Vol. 35, Issue 3; Other Information: DOI: 10.1007/s00270-011-0215-x; Copyright (c) 2012 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Country of input: International Atomic Energy Agency (IAEA); ISSN 0174-1551
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ADULTS
ARTERIES
BIOMEDICAL RADIOGRAPHY
CASTING MOLDS
FEMALES
GELATIN
GUINEA PIGS
INFLAMMATION
MICROSPHERES
NECROSIS
SWINE
UTERUS
AGE GROUPS
ANIMALS
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
COLLOIDS
DIAGNOSTIC TECHNIQUES
DISPERSIONS
DOMESTIC ANIMALS
FEMALE GENITALS
MAMMALS
MEDICINE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PROTEINS
RADIOLOGY
RODENTS
SYMPTOMS
VERTEBRATES