Porous Gelatin Particles for Uterine Artery Embolization: An Experimental Study of Intra-Arterial Distribution, Uterine Necrosis, and Inflammation in a Porcine Model

Journal Article · Fri Oct 15 04:00:00 EDT 2010 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-010-9935-6· OSTI ID:21428909

Sone, Miyuki ^[1]; Osuga, Keigo ^[2]; Shimazu, Kohki ^[3]; Higashihara, Hiroki; Nakazawa, Tetsuro ^[2]; Kato, Kenichi; Tomabechi, Makiko; Ehara, Shigeru ^[1]; Nakamura, Hironobu ^[2]; Morii, Eiichi; Aozasa, Katsuyuki ^[3]

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1. Iwate Medical University, Department of Radiology (Japan)
2. Osaka University Graduate School of Medicine, Department of Diagnostic and Interventional Radiology (Japan)
3. Osaka University Graduate School of Medicine, Department of Pathology (Japan)

PurposeWe evaluated the location of porous gelatin particles (GP; Gelpart; Nippon Kayaku/Astellas, Tokyo, Japan) within the arterial vasculature and their acute effects on uterine necrosis and inflammation after uterine artery embolization (UAE) in swine.Materials and MethodsAdult nonpregnant pigs (n = 6) were allocated to either 1- (n = 3) or 2-mm GP (n = 3). Superselective and bilateral embolization of the uterine arteries was performed. All animals were killed 1 week after UAE. Macroscopic and microscopic findings, including the level of arterial occlusion and their effect on uterine necrosis and inflammation, were analyzed.ResultsAll UAE procedures were completed without severe complications. The macroscopic necrosis was seen in two animals in the 2-mm group with an extent of <50%. The location of the occluded arteries did not differ significantly between groups. The median diameters of the occluded arteries were 449 {mu}m (95% confidence interval [CI] 417-538 {mu}m) in the 1-mm GP group and 484 {mu}m (95% CI 370-560 {mu}m) in the 2-mm GP group. As for microscopic necrosis, no statistically significant difference was observed. The qualitative inflammatory reaction was significantly greater in the 2-mm GP group than in the 1-mm group (p < 0.001).ConclusionsBoth 1- and 2-mm GP occluded the arteries relevant to the target diameter for UAE in porcine uterus, presumably due to the plastic deformity. Both sizes of GP were associated with limited areas of necrosis; however, evaluation of inflammatory reaction was preliminary. Further study with adequate evaluation of inflammatory reactions is suggested.

• OSTI ID: 21428909
• Journal Information: Cardiovascular and Interventional Radiology, Journal Name: Cardiovascular and Interventional Radiology Journal Issue: 5 Vol. 33; ISSN 0174-1551; ISSN CAIRDG
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ARTERIES
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
COLLOIDS
DISPERSIONS
DOMESTIC ANIMALS
EMBOLI
FEMALE GENITALS
GELATIN
INFLAMMATION
MAMMALS
MATERIALS
NECROSIS
ORGANIC COMPOUNDS
ORGANS
PARTICLES
PATHOLOGICAL CHANGES
POROUS MATERIALS
PROTEINS
SWINE
SYMPTOMS
UTERUS
VERTEBRATES