Dosimetry of Radiopharmaceuticals for Diagnostic and Therapeutic Nuclear Medicine

Journal Article · Thu May 05 00:00:00 EDT 2011 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.3576158· OSTI ID:21608109

Smart, Richard ^[1]

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1. Department of Nuclear Medicine, St George Hospital, Kogarah, NSW 2217 (Australia)

A standard formalism for radionuclide internal radiation dosimetry was developed in the 1960s and continues to be refined today. Early work was based on a mathematical phantom but this is being replaced by phantoms developed from whole-body CT scans to give more realistic dose estimates. The largest contributors to the uncertainties in these dose estimates are the errors associated with in vivo activity quantitation, the variability of the biokinetics between patients and the limited information that can be obtained on these kinetics in individual patients. Despite these limitations, pre-treatment patient-specific dosimetry is being increasing used, particularly to limit the toxicity to non-target organs such as the bone marrow.

• OSTI ID: 21608109
• Journal Information: AIP Conference Proceedings, Vol. 1345, Issue 1; Conference: SSD summer school on concepts and trends in medical radiation dosimetry, Wollongong (Australia), 15-18 Sep 2010; Other Information: DOI: 10.1063/1.3576158; (c) 2011 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
61 RADIATION PROTECTION AND DOSIMETRY
BONE MARROW
CAT SCANNING
DOSES
DOSIMETRY
IN VIVO
PATIENTS
PHANTOMS
RADIOPHARMACEUTICALS
RADIOTHERAPY
TOXICITY
ANIMAL TISSUES
BODY
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DRUGS
HEMATOPOIETIC SYSTEM
LABELLED COMPOUNDS
MATERIALS
MEDICINE
MOCKUP
NUCLEAR MEDICINE
ORGANS
RADIOACTIVE MATERIALS
RADIOLOGY
STRUCTURAL MODELS
THERAPY
TOMOGRAPHY