Deactivation of A549 cancer cells in vitro by a dielectric barrier discharge plasma needle
- Institute of Physics, Chinese Academy of Sciences, Beijing 100190 (China)
- Pakistan Institute of Technology for Mineral and Advanced Engineering Material, Ferozepur Road, Lahore-54600 (Pakistan)
- College of Science, Changchun University of Science and Technology, Changchun 130022 (China)
An inactivation mechanism study on A549 cancer cells by means of a dielectric barrier discharge plasma needle is presented. The neutral red uptake assay provides a quantitative estimation of cell viability after plasma treatment. Experimental results show that the efficiency of argon plasma for the inactivation process is very dependent on power and treatment time. A 27 W power and 120 s treatment time along with 900 standard cubic centimeter per minute Ar flow and a nozzle-to-sample separation of 3 mm are the best parameters of the process. According to the argon emission spectra of the plasma jet and the optical microscope images of the A549 cells after plasma treatment, it is concluded that the reactive species (for example, OH and O) in the argon plasma play a major role in the cell deactivation.
- OSTI ID:
- 21538140
- Journal Information:
- Journal of Applied Physics, Vol. 109, Issue 5; Other Information: DOI: 10.1063/1.3553873; (c) 2011 American Institute of Physics; ISSN 0021-8979
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
AMINES
ANIMAL CELLS
ARGON
ARGON IONS
DEACTIVATION
DIELECTRIC MATERIALS
ELECTRIC DISCHARGES
EMISSION SPECTRA
IN VITRO
INACTIVATION
IONIZING RADIATIONS
LASER RADIATION
NEOPLASMS
ONCOGENES
OPTICAL MICROSCOPY
PLASMA
PLASMA JETS
PROLIFERATION
TRANSFORMATIONS
CHARGED PARTICLES
DISEASES
ELECTROMAGNETIC RADIATION
ELEMENTS
FLUIDS
GASES
GENES
IONS
MATERIALS
MICROSCOPY
NONMETALS
ORGANIC COMPOUNDS
RADIATIONS
RARE GASES
SPECTRA