Cold atmospheric pressure plasma jet interactions with plasmid DNA

Journal Article · Mon Jan 24 00:00:00 EST 2011 · Applied Physics Letters

DOI:https://doi.org/10.1063/1.3521502· OSTI ID:21518266

O'Connell, D; Cox, L J; Hyland, W B; McMahon, S J; Reuter, S; Graham, W G; Gans, T; Currell, F J ^[1]

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1. Centre for Plasma Physics, School of Mathematics and Physics, Queen's University Belfast, University Road, Belfast BT7 1NN, Northern Ireland (United Kingdom)

The effect of a cold (<40 deg. C) radio frequency-driven atmospheric pressure plasma jet on plasmid DNA has been investigated. Gel electrophoresis was used to analyze the DNA forms post-treatment. The experimental data are fitted to a rate equation model that allows for quantitative determination of the rates of single and double strand break formation. The formation of double strand breaks correlates well with the atomic oxygen density. Taken with other measurements, this indicates that neutral components in the jet are effective in inducing double strand breaks.

• OSTI ID: 21518266
• Journal Information: Applied Physics Letters, Vol. 98, Issue 4; Other Information: DOI: 10.1063/1.3521502; (c) 2011 American Institute of Physics; ISSN 0003-6951
• Country of Publication: United States
• Language: English

Related Subjects

74 ATOMIC AND MOLECULAR PHYSICS
70 PLASMA PHYSICS AND FUSION TECHNOLOGY
ATMOSPHERIC PRESSURE
COLLISIONS
DENSITY
DNA
ELECTROPHORESIS
GELS
INTERACTIONS
OXYGEN
PLASMA
PLASMA JETS
RADIOWAVE RADIATION
REACTION KINETICS
STRAND BREAKS
COLLOIDS
DISPERSIONS
DNA DAMAGES
ELECTROMAGNETIC RADIATION
ELEMENTS
KINETICS
NONMETALS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PHYSICAL PROPERTIES
RADIATIONS