Dose-Response Effect of Charged Carbon Beam on Normal Rat Retina Assessed by Electroretinography

Journal Article · Wed Dec 01 00:00:00 EST 2010 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2010.07.003· OSTI ID:21499705

Mizota, Atsushi ^[1]; Tanaka, Minoru ^[2]; Kubota, Mariko; Negishi, Hisanari ^[3]; Watanabe, Emiko ^[1]; Tsuji, Hiroshi; Miyahara, Nobuyuki; Furusawa, Yoshiya ^[4]

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1. Department of Ophthalmology, Teikyo University School of Medicine, Tokyo (Japan)
2. Department of Ophthalmology, Juntendo University Urayasu Hospital, Urayasu (Japan)
3. Department of Ophthalmology, National Hospital Organization Chiba Medical Center, Chiba (Japan)
4. National Institute of Radiological Sciences, Chiba (Japan)

Purpose: To compare the effects of carbon beam irradiation with those of proton beam irradiation on the physiology of the retina of rats. Methods and Materials: Eight-week-old Wister rats were used. The right eyes were irradiated with carbon beam (1, 2, 4, 8, and 16 Gy) or proton beam (4, 8, 16, and 24 Gy) with the rats under general anesthesia. Electroretinograms were recorded 1, 3, 6, and 12 months after the irradiation, and the amplitudes of the a and b waves were compared with those of control rats. Results: The amplitude of b waves was reduced more than that of a waves at lower irradiation doses with both types of irradiation. With carbon ion irradiation, the amplitudes of the b wave were significantly reduced after radiation doses of 8 and 16 Gy at 6 months and by radiation doses of 4, 8, and 16 Gy at 12 months. With proton beam irradiation, the b-wave amplitudes were significantly reduced after 16 and 24 Gy at 6 months and with doses of 8 Gy or greater at 12 months. For the maximum b-wave amplitude, a significant difference was observed in rats irradiated with carbon beams of 4 Gy or more and with proton beams of 8 Gy or more at 12 months after irradiation. Conclusions: These results indicate that carbon beam irradiation is about two times more damaging than proton beam irradiation on the rat retina at the same dose.

• OSTI ID: 21499705
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Vol. 78, Issue 5; Other Information: DOI: 10.1016/j.ijrobp.2010.07.003; PII: S0360-3016(10)00901-6; Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS
62 RADIOLOGY AND NUCLEAR MEDICINE
CARBON IONS
DOSE-RESPONSE RELATIONSHIPS
PROTON BEAMS
RADIATION DOSES
RADIATION INJURIES
RATS
RETINA
ANIMALS
BEAMS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CHARGED PARTICLES
DISEASES
DOSES
EYES
FACE
HEAD
INJURIES
IONS
MAMMALS
NUCLEON BEAMS
ORGANS
PARTICLE BEAMS
RADIATION EFFECTS
RODENTS
SENSE ORGANS
VERTEBRATES