Effect of amine functionalization of spherical MCM-41 and SBA-15 on controlled drug release

Journal Article · Sun May 15 00:00:00 EDT 2011 · Journal of Solid State Chemistry

DOI:https://doi.org/10.1016/j.jssc.2011.03.005· OSTI ID:21494299

Szegedi, A ^[1]; Popova, M; Goshev, I ^[2]; Mihaly, J ^[1]

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1. Institute of Nanochemistry and Catalysis, Chemical Research Center, Hungarian Academy of Sciences, 1025 Budapest, Pusztaszeri ut 59-67 (Hungary)
2. Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia (Bulgaria)

MCM-41 and SBA-15 silica materials with spherical morphology and different particle sizes were synthesized and modified by post-synthesis method with 3-aminopropyltriethoxysilane (APTES). A comparative study of the adsorption and release of a model drug, ibuprofen, were carried out. The modified and drug loaded mesoporous materials were characterized by XRD, TEM, N{sub 2} physisorption, thermal analysis, elemental analysis and FT-IR spectroscopy. Surface modification with amino groups resulted in high degree of ibuprofen loading and slow rate of release for MCM-41, whereas it was the opposite for SBA-15. The adsorbed drug content and the delivery rate can be predetermined by the choice of mesoporous material with the appropriate structural characteristics and surface functionality. -- Graphical Abstract: Ibuprofen delivery from the parent and amino-modified spherical MCM-41 materials with 100 nm (small) and 500 nm (large) particle sizes. Display Omitted Highlights: {yields} Spherical type MCM-41 and SBA-15 with different particle sizes were modified by APTES. {yields} Adsorption and release rate of ibuprofen were compared. {yields} High degree of ibuprofen loading, slow release rate for MCM-41, the opposite for SBA-15. {yields} MCM-41 with 100 nm particles was more stable and showed slower release rate

• OSTI ID: 21494299
• Journal Information: Journal of Solid State Chemistry, Vol. 184, Issue 5; Other Information: DOI: 10.1016/j.jssc.2011.03.005; PII: S0022-4596(11)00102-2; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; ISSN 0022-4596
• Country of Publication: United States
• Language: English

Related Subjects

77 NANOSCIENCE AND NANOTECHNOLOGY
ADSORPTION
DELIVERY
DRUGS
INFRARED SPECTRA
NANOSTRUCTURES
PARTICLE SIZE
SILICA
SPHERICAL CONFIGURATION
SURFACES
SYNTHESIS
THERMAL ANALYSIS
TRANSMISSION ELECTRON MICROSCOPY
X-RAY DIFFRACTION
COHERENT SCATTERING
CONFIGURATION
DIFFRACTION
ELECTRON MICROSCOPY
MICROSCOPY
MINERALS
OXIDE MINERALS
SCATTERING
SIZE
SORPTION
SPECTRA