Functionalized bimodal mesoporous silicas as carriers for controlled aspirin delivery
- Department of Chemistry and Chemical Engineering, College of Environmental and Energy Engineering, Beijing University of Technology, Beijing 100124 (China)
The bimodal mesoporous silica modified with 3-aminopropyltriethoxysilane was performed as the aspirin carrier. The samples' structure, drug loading and release profiles were characterized with X-ray diffraction, scanning electron microscopy, N{sub 2} adsorption and desorption, Fourier transform infrared spectroscopy, TG analysis, elemental analysis and UV-spectrophotometer. For further exploring the effects of the bimodal mesopores on the drug delivery behavior, the unimodal mesoporous material MCM-41 was also modified as the aspirin carrier. Meantime, Korsmeyer-Peppas equation f{sub t}=kt{sup n} was employed to analyze the dissolution data in details. It is indicated that the bimodal mesopores are beneficial for unrestricted drug molecules diffusing and therefore lead to a higher loading and faster releasing than that of MCM-41. The results show that the aspirin delivery properties are influenced considerably by the mesoporous matrix, whereas the large pore of bimodal mesoporous silica is the key point for the improved controlled-release properties. - Graphical abstract: Loading (A) and release profiles (B) of aspirin in N-BMMs and N-MCM-41 indicated that BMMs have more drug loading capacity and faster release rate than that MCM-41. Highlights: > Bimodal mesoporous silicas (BMMs) and MCM-41 modified with amino group via post-treatment procedure. > Loading and release profiles of aspirin in modified BMMs and MCM-41. > Modified BMMs have more drug loading capacity and faster release rate than that modified MCM-41.
- OSTI ID:
- 21580208
- Journal Information:
- Journal of Solid State Chemistry, Vol. 184, Issue 8; Other Information: DOI: 10.1016/j.jssc.2011.05.052; PII: S0022-4596(11)00301-X; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; ISSN 0022-4596
- Country of Publication:
- United States
- Language:
- English
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ORGANIC
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ACETYLSALICYLIC ACID
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DESORPTION
FOURIER TRANSFORM SPECTROMETERS
NANOSTRUCTURES
SCANNING ELECTRON MICROSCOPY
SILICA
SPECTROPHOTOMETERS
THERMAL GRAVIMETRIC ANALYSIS
X-RAY DIFFRACTION
ANALGESICS
ANTIPYRETICS
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHEMICAL ANALYSIS
COHERENT SCATTERING
DIFFRACTION
DRUGS
ELECTRON MICROSCOPY
GRAVIMETRIC ANALYSIS
HYDROXY ACIDS
MEASURING INSTRUMENTS
MICROSCOPY
MINERALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
OXIDE MINERALS
QUANTITATIVE CHEMICAL ANALYSIS
SCATTERING
SORPTION
SPECTROMETERS
THERMAL ANALYSIS