A New Ischemic Model Using a Radiofrequency Wire Electrode in a Rabbit Hindlimb

Journal Article · Tue Jul 15 04:00:00 EDT 2008 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-008-9302-Z· OSTI ID:21450363

Shim, Hyung Jin ^[1]; Kim, Yang Soo ^[2]; Lee, Jong Beom; Kim, Kun Sang ^[1]

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1. Chung-Ang University College of Medicine, Department of Radiology, Yongsan Hospital (Korea, Republic of)
2. Chung-Ang University College of Medicine, Department of Radiology, Chung-Ang University Hospital (Korea, Republic of)

The purpose of this study was to establish an ischemic rabbit hindlimb model using a radiofrequency (RF) wire electrode. We inserted a polytetrafluoroethylene-coated wire with a 2-cm exposed tip into the left superficial femoral artery of seven New Zealand white rabbits and performed RF ablation (RFA) while pulling the wire back. We assessed the clinical findings, angiography, computed tomography perfusion, and permeability surface until 6 weeks after RFA. The angiography demonstrated complete obstruction from the proximal external iliac artery to the distal superficial femoral artery and showed a gradual increment in the angiogenic score, which represents the degree of angiogenesis (r = 0.86, p < 0.0001). The left-to-right ratios of the computed tomography perfusion and permeability surface were significantly reduced after 4 days (p < 0.05), and then they gradually increased with time. We conclude that endovascular RFA using an RF wire electrode is a reproducible and measurable way to create an ischemic rabbit hindlimb model.

• OSTI ID: 21450363
• Journal Information: Cardiovascular and Interventional Radiology, Journal Name: Cardiovascular and Interventional Radiology Journal Issue: 4 Vol. 31; ISSN 0174-1551; ISSN CAIRDG
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ABLATION
ANGIOGENESIS
ANIMALS
ARTERIES
BIOMEDICAL RADIOGRAPHY
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
ELECTRODES
ELECTROMAGNETIC RADIATION
FLUORINATED ALIPHATIC HYDROCARBONS
HALOGENATED ALIPHATIC HYDROCARBONS
MAMMALS
MEDICINE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC POLYMERS
ORGANS
PERMEABILITY
PHYSICAL PROPERTIES
POLYETHYLENES
POLYMERS
POLYOLEFINS
POLYTETRAFLUOROETHYLENE
RABBITS
RADIATIONS
RADIOLOGY
RADIOWAVE RADIATION
TOMOGRAPHY
VERTEBRATES
WIRES