Design of an Automated System for Synthesis of [18 F] FDG for PET Investigation at IFIN-HH Bucharest
- Applied Nuclear Physics Department, 'Horia Hulubei' National Institute for Physics and Nuclear Engineering, Atomistilor 407, P.O. Box MG-6, Magurele, jud. Ilfov, Bucharest R-077125 (Romania)
A novel apparatus constructed at IFIN-HH is described for automated synthesis of radiopharmaceuticals labeled with {sup 18}F for use in positron emission tomography (PET) investigations. [18 F] fluoride was produced at the IFIN-HH cyclotron by irradiation of H{sub 2}O enriched 97% in {sup 18}O with 13 MeV deuterons, or 8 MeV protons. The irradiated H{sub 2}O was transferred (injected) into the radiochemical fully-automated processing systems which ensured the separation of {sup 18}F from H{sub 2}O, the labeling with {sup 18}F, and finally purified by filtration with selective absorbants. The system is easy to operate and contains a programmable logical controller that manages the entire operation program stored in its internal memory. The computer is used to assist the operator during the different steps of synthesis and to allow visualization of the process and printing the report. The device was used for used for the production of 2-[18 F] FLUORO-2-DEOXY-D-GLUCOSE at the IFIN-HH cyclotron, one of the most used radiopharmaceutical in PET investigations. The synthesis module is configured so that is flexible enough to accomplish other nucleophile reactions of labeling with short lived radioisotopes.
- OSTI ID:
- 21289580
- Journal Information:
- AIP Conference Proceedings, Vol. 1099, Issue 1; Conference: CAARI 2008: 12. international conference on application of accelerators in research and industry, Fort Worth, TX (United States), 10-15 Aug 2008; Other Information: DOI: 10.1063/1.3120082; (c) 2009 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-243X
- Country of Publication:
- United States
- Language:
- English
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