Lacrimal Gland Radiosensitivity in Uveal Melanoma Patients

Journal Article · Mon Jun 01 04:00:00 EDT 2009 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2008.08.010· OSTI ID:21276829

Muller, Karin ^[1]; Naus, Nicole ^[2]; Pan, Connie de ^[1]; Santen, Cornelis A. van ^[2]; Levendag, Peter ^[1]; Luyten, Gre P.M. ^[3]

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1. Department of Radiation-Oncology, Erasmus Medical Center, Rotterdam (Netherlands)
2. Department of Ophthalmology, Erasmus Medical Center, Rotterdam (Netherlands)
3. Department of Ophthalmology, Leids University Medical Center, Leiden (Netherlands)

Purpose: To find a dose-volume effect for inhomogeneous irradiated lacrimal glands. Methods and Materials: Between 1999 and 2006, 72 patients (42 men and 30 women) were treated with fractionated stereotactic radiotherapy in a prospective, nonrandomized clinical trial (median follow-up, 32 months). A total dose of 50 Gy was given on 5 consecutive days. The mean of all Schirmer test results obtained {>=}6 months after treatment was correlated with the radiation dose delivered to the lacrimal gland. Also, the appearance of dry eye syndrome (DES) was related to the lacrimal gland dose distribution. Results: Of the 72 patients, 17 developed a late Schirmer value <10 mm; 9 patients developed DES. A statistically significant relationship was found between the received median dose in the lacrimal gland vs. reduced tear production (p = 0.000) and vs. the appearance of DES (p = 0.003), respectively. A median dose of 7 Gy/fraction to the lacrimal gland caused a 50% risk of low Schirmer results. A median dose of 10 Gy resulted in a 50% probability of DES. Conclusion: We found a clear dose-volume relationship for irradiated lacrimal glands with regard to reduced tear production and the appearance of DES.

• OSTI ID: 21276829
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 2 Vol. 74; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CLINICAL TRIALS
GLANDS
HAZARDS
MELANOMAS
MEN
PATIENTS
RADIATION DOSE DISTRIBUTIONS
RADIATION DOSES
RADIOSENSITIVITY
RADIOTHERAPY
TOXICITY
WOMEN