Lacrimal gland dosimetry for the brain imaging agent technetium-99m-HMPAO

Journal Article · Sun Jul 01 04:00:00 EDT 1990 · Journal of Nuclear Medicine; (USA)

OSTI ID:6609517

Villanueva-Meyer, J; Thompson, D; Mena, I; Marcus, C S ^[1]

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1. Harbor-UCLA Medical Center, Torrance, CA (USA)

We calculated lacrimal gland dosimetry for the brain imaging agent {sup 99m}Tc-HMPAO. One hundred thirty-eight patients were studied using a dedicated brain imaging device. Only 11% of the patients showed lacrimal gland uptake. For a 740-MBq (20 mCi) injected dose of {sup 99m}Tc-HMPAO, the radiation exposure to the lacrimal glands is 10.2 mGy (1.02 rad), or 0.0138 mGy/MBq (0.051 rad/mCi). These values are five times lower than the ones reported by the manufacturer of HMPAO. As the dosimetry calculation is only for subjects showing {sup 99m}Tc-HMPAO uptake in the lacrimal gland, the average radiation dose to all subjects is considerably lower, 1/10 of the estimated value.

• OSTI ID: 6609517
• Journal Information: Journal of Nuclear Medicine; (USA), Journal Name: Journal of Nuclear Medicine; (USA) Vol. 31:7; ISSN 0161-5505; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BODY AREAS
BRAIN
CENTRAL NERVOUS SYSTEM
DOSES
DOSIMETRY
DRUGS
EYES
FACE
GLANDS
HEAD
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
IMAGE PROCESSING
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MAN
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIMES
PATIENTS
PRIMATES
PROCESSING
RADIATION DOSES
RADIOISOTOPES
RADIOPHARMACEUTICALS
SENSE ORGANS
TECHNETIUM 99
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES