Adiponectin stimulates IL-8 production by rheumatoid synovial fibroblasts

Journal Article · Fri Jan 09 04:00:00 EST 2009 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/j.bbrc.2008.11.017· OSTI ID:21255824

Kitahara, Kanako ^[1]; Kusunoki, Natsuko ^[1]; Kakiuchi, Terutaka ^[2]; Suguro, Toru ^[3]; Kawai, Shinichi ^[1]

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1. Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, 6-11-1 Omori-Nishi, Ota-ku, Tokyo 143-8541 (Japan)
2. Department of Immunology, Toho University School of Medicine, Tokyo (Japan)
3. Department of Orthopaedic Surgery, Toho University School of Medicine, Tokyo (Japan)

The adipokines are linked not only to metabolic regulation, but also to immune responses. Adiponectin, but not leptin or resistin induced interleukin-8 production from rheumatoid synovial fibroblasts (RSF). The culture supernatant of RSF treated with adiponectin induced chemotaxis, although adiponectin itself had no such effect. Addition of antibody against adiponectin, and inhibition of adiponectin receptor gene decreased adiponectin-induced IL-8 production. Nuclear translocation of nuclear factor-kappa B was increased by adiponectin. The induction of interleukin-8 was inhibited by mitogen-activated protein kinase inhibitors. These findings suggest that adiponectin contributes to the pathogenesis of rheumatoid arthritis.

• OSTI ID: 21255824
• Journal Information: Biochemical and Biophysical Research Communications, Journal Name: Biochemical and Biophysical Research Communications Journal Issue: 2 Vol. 378; ISSN 0006-291X; ISSN BBRCA9
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ANTIBODIES
FIBROBLASTS
GENES
INFLAMMATION
INHIBITION
LEPTIN
PATHOGENESIS
RHEUMATIC DISEASES