Captopril to Mitigate Chronic Renal Failure After Hematopoietic Stem Cell Transplantation: A Randomized Controlled Trial

Journal Article · Tue Apr 01 00:00:00 EDT 2008 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2007.08.041· OSTI ID:21124166

Irving, Amy A. B.A. ^[1]; Drobyski, William R ^[2]; Klein, John P ^[3]; Passweg, Jakob ^[2]; Talano, Julie-An M ^[4]; Juckett, Mark B ^[2]; Moulder, John E ^[1]

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1. Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI (United States)
2. Department of Medicine, Medical College of Wisconsin, Milwaukee, WI (United States)
3. Department of Population Health, Medical College of Wisconsin, Milwaukee, WI (United States)
4. Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI (United States)

Purpose: To test whether the angiotensin-converting enzyme inhibitor captopril was effective in mitigating chronic renal failure after hematopoietic stem cell transplantation (HSCT). Methods and Materials: A total of 55 subjects undergoing total body irradiation (TBI)-HSCT were enrolled in this randomized controlled trial. Captopril or identical placebo was started at engraftment and continued as tolerated until 1 year after HSCT. Results: The baseline serum creatinine and calculated glomerular filtration rate (GFR) did not differ between groups. The 1-year serum creatinine level was lower and the GFR higher in the captopril compared with the placebo group (p = 0.07 for GFR). Patient survival was higher in the captopril compared with the placebo group, but this was also not statistically significant (p = 0.09). In study subjects who received the study drug for more than 2 months, the 1-year calculated GFRs were 92 mL/min and 80 mL/min, for the captopril and placebo groups, respectively (p = 0.1). There was no adverse effect on hematologic outcome. Conclusions: There is a trend in favor of captopril in mitigation of chronic renal failure after radiation-based HSCT.

• OSTI ID: 21124166
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Vol. 70, Issue 5; Other Information: DOI: 10.1016/j.ijrobp.2007.08.041; PII: S0360-3016(07)03992-2; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANGIOTENSIN
CREATININE
ENZYME INHIBITORS
FAILURES
KIDNEYS
STEM CELLS
WHOLE-BODY IRRADIATION