Low-Dose Hyper-Radiosensitivity: Past, Present, and Future

Journal Article · Tue Apr 01 04:00:00 EDT 2008 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2007.11.071· OSTI ID:21124131

Marples, Brian ^[1]; Collis, Spencer J ^[2]

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1. Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI (United States)
2. DNA Damage Response Laboratory, Cancer Research U.K., Clare Hall Laboratories, South Mimms (United Kingdom)

This review article discusses the biology of low-dose hyper-radiosensitivity (HRS) with reference to the molecular regulation of DNA repair and cell cycle control processes. Particular attention is paid to the significance of G2-phase cell cycle checkpoints in overcoming low-dose hyper-radiosensitivity and the impact of HRS on low-dose rate radiobiology. The history of HRS from the original in vivo discovery to the most recent in vitro and clinical data are examined to present a unifying hypothesis concerning the molecular control and regulation of this important low dose radiation response. Finally, preclinical and clinical data are discussed, from a molecular viewpoint, to provide theoretical approaches to exploit HRS biology for clinical gain.

• OSTI ID: 21124131
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 5 Vol. 70; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CELL CYCLE
DNA REPAIR
DOSE RATES
IN VITRO
IONIZING RADIATIONS
RADIATION DOSES
RADIOBIOLOGY
RADIOSENSITIVITY
REGULATIONS