{sup 119}Sb--A potent Auger emitter for targeted radionuclide therapy
- Hevesy Laboratory, Radiation Research Department, Risoe National Laboratory for Sustainable Energy, Technical University of Denmark, P.O. 49, DK-4000 Roskilde (Denmark) and Department of Natural Sciences, Faculty of Life Sciences, University of Copenhagen, DK-1871 Frederiksberg (Denmark)
Auger electron emitting radionuclides in cancer therapy offer the opportunity to deliver a high radiation dose to the tumor cells with high radiotoxicity while minimizing toxicity to normal tissue. We have in this study identified the Auger emitter {sup 119}Sb as a potent nuclide for targeted radionuclide therapy based on theoretical dosimetry calculations at a subcellular scale. From these calculations we have determined the cellular S-values for this therapeutic isotope. Moreover, we have demonstrated the possibility of producing this isotope and also the SPECT-analogue {sup 117}Sb for patient-specific dosimetry, by measuring the proton irradiation yields for both isotopes using a low-energy cyclotron. The excellent SPECT imaging properties of the {sup 117}Sb radionuclide have been shown by scanning a Jaszczak SPECT Phantom.
- OSTI ID:
- 21120897
- Journal Information:
- Medical Physics, Journal Name: Medical Physics Journal Issue: 9 Vol. 35; ISSN 0094-2405; ISSN MPHYA6
- Country of Publication:
- United States
- Language:
- English
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